Influence of catechins on bystander responses in CHO cells induced by alpha-particle irradiation

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Original languageEnglish
Pages (from-to)726-729
Journal / PublicationApplied Radiation and Isotopes
Issue number4-5
Publication statusPublished - Apr 2010


In this work, we studied alpha-particle induced and medium-mediated bystander effects in Chinese hamster ovary (CHO) cells through micronucleus (MN) assay. We showed that signal transduction from irradiated cells to bystander cells occur within a short time after irradiation. We then studied the effects of ROS (reactive oxygen species)-scavenging catechins in the medium before irradiation. We observed decreases in the percentage of bystander cells with MN formation and thus proved the protection effect of catechins on bystander cells from radiation. © 2009 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Alpha-particle, Bystander effect, Catechins, CHO cells