Inflammatory bowel disease : How effective is TNF-α suppression?

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Original languageEnglish
Article numbere0165782
Journal / PublicationPLoS ONE
Volume11
Issue number11
Publication statusPublished - 1 Nov 2016

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Abstract

Crohn's Disease (CD) results from inappropriate response toward commensal flora. Earlier studies described CD as a Th1 mediated disease. Current models view both phenotypes as a continuum of various permutations between Th1, Th2 and Th17 pathways compounded by a range of Treg disfunctions. In the present paper, we develop a mathematical model, by a system of differential equations, which describe the dynamic relations among these T cells and their cytokines. The model identities four groups of CD patients according to up/down regulation of Th1 and Th2. The model simulations show that immunosuppression by TNF-α blockage benefits the group with Th1High/Th2Low while, by contrast, the group with Th1Low/Th2High will benefit from immune activation.

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Inflammatory bowel disease : How effective is TNF-α suppression? / Lo, Wing-Cheong; Arsenescu, Violeta; Arsenescu, Razvan I.; Friedman, Avner.

In: PLoS ONE, Vol. 11, No. 11, e0165782, 01.11.2016.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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