Induction of NG108-15 cells differrentiation by human bone marrow stromal cells
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 1365-1369 |
Journal / Publication | NeuroReport |
Volume | 9 |
Issue number | 7 |
Publication status | Published - 11 May 1998 |
Externally published | Yes |
Link(s)
Abstract
The survival and differentiation of neuronal cells is dependent on factors such as neurotrophins, cytokines and components of extracellular matrix. Bone marrow stromal cells have been shown to support the growth and differentiation of neuroblastoma cells. In an attempt to study the effects of bone marrow stromal cells on neuronal differentiation, we have co-cultured neuroblastoma x glioma hybrid NG108-15 cells with human bone marrow stromal cells. After co-culturing, clones exhibiting morphological differentiated phenotype and high level of neurofilament expression were isolated. Interestingly, these clones maintain their ability to proliferate in contrast to differentiated NG108-15 cells induced by dibutyryladenosine 3',5'-cyclic monophosphate. These results suggested that bone marrow stromal cells can induce partial differentiation of NG108-15 cells.
Research Area(s)
- Bone marrow stromal cells, Neuroblastoma differentiation, Neurofilament
Citation Format(s)
Induction of NG108-15 cells differrentiation by human bone marrow stromal cells. / Ho, Siu-Hong; So, Lac-Hue; Lai, Kwok-On et al.
In: NeuroReport, Vol. 9, No. 7, 11.05.1998, p. 1365-1369.
In: NeuroReport, Vol. 9, No. 7, 11.05.1998, p. 1365-1369.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review