Induction of macrophage polarization by electrospun nano-yarn containing naproxen sodium to promote tendon repair

Xiao Yu; Guiwang Shen; Jiujiu Yan; Wanxin Guo; Zhengchao Yuan; Jie Cui; Yihong Shen; Pengfei Cai; Yujie Chen; Tsz Ngai Mok; Mohamed EL-Newehy; Hany EL-Hamshary; Binbin Sun; Jieruo Li; Xiumei Mo

doi:10.1016/j.apmt.2024.102070

Induction of macrophage polarization by electrospun nano-yarn containing naproxen sodium to promote tendon repair

Xiao Yu, Guiwang Shen, Jiujiu Yan, Wanxin Guo, Zhengchao Yuan, Jie Cui, Yihong Shen, Pengfei Cai, Yujie Chen, Tsz Ngai Mok, Mohamed EL-Newehy, Hany EL-Hamshary, Binbin Sun^*, Jieruo Li^*, Xiumei Mo^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

10 Citations (Scopus)

Abstract

Excessive inflammatory response can lead to failure of the tendon repair surgery. Tendon substitutes that can effectively balance inflammatory responses and have sufficient mechanical properties are one of the key factors in promoting repair. In this study, the nanofibers containing the naproxen sodium were attached to polylactic acid micron yarn by electrospinning to obtain double-layer core-spun yarn (DY). The DY was knitted into a tendon tissue engineering scaffold with sufficient mechanical properties. This study confirmed the optimal loading concentration of naproxen sodium. The results in vitro and in vivo indicated that sustained-release naproxen sodium in scaffolds could effectively inhibit the rapid proliferation of foreign fibroblasts, accelerate the polarization of macrophages, reduce the inflammatory response, and promote tendon tissue repair. This study provides a new scaffold for tendon tissue engineering that not only serves as a substitute for tendon repair, but also serves as an anti-inflammatory agent to better promote the repair process. © 2024 Elsevier Ltd.

Original language	English
Article number	102070
Journal	Applied Materials Today
Volume	36
Online published	18 Jan 2024
DOIs	https://doi.org/10.1016/j.apmt.2024.102070
Publication status	Published - Feb 2024

Funding

This research was supported by Science and Technology Commission of Shanghai Municipality, China (No. 20S31900900 , 20DZ2254900 ) and Sino German Science Foundation Research Exchange Center, China ( M-0263 ), China Education Association for International Exchange ( 2022181 ). This project was also supported by Researchers Supporting Project Number ( RSP2024R65 ), King Saud University, Riyadh, Saudi Arabia . This project was also funding by Science and Technology Projects in Guangzhou (No. 202201020056 ) and the Clinical Frontier Technology Program of the First Affiliated Hospital of Jinan University, China (No. JNU1AF-CFTP-2022-a01204 ). This project was also supported by the Fundamental Research Funds for the Central Universities ( CUSF-DH-T-2023063 ).

Research Keywords

Anti-inflammatory
Electrospinning
Naproxen sodium
Tendon repair

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title = "Induction of macrophage polarization by electrospun nano-yarn containing naproxen sodium to promote tendon repair",

abstract = "Excessive inflammatory response can lead to failure of the tendon repair surgery. Tendon substitutes that can effectively balance inflammatory responses and have sufficient mechanical properties are one of the key factors in promoting repair. In this study, the nanofibers containing the naproxen sodium were attached to polylactic acid micron yarn by electrospinning to obtain double-layer core-spun yarn (DY). The DY was knitted into a tendon tissue engineering scaffold with sufficient mechanical properties. This study confirmed the optimal loading concentration of naproxen sodium. The results in vitro and in vivo indicated that sustained-release naproxen sodium in scaffolds could effectively inhibit the rapid proliferation of foreign fibroblasts, accelerate the polarization of macrophages, reduce the inflammatory response, and promote tendon tissue repair. This study provides a new scaffold for tendon tissue engineering that not only serves as a substitute for tendon repair, but also serves as an anti-inflammatory agent to better promote the repair process. {\textcopyright} 2024 Elsevier Ltd.",

keywords = "Anti-inflammatory, Electrospinning, Naproxen sodium, Tendon repair",

author = "Xiao Yu and Guiwang Shen and Jiujiu Yan and Wanxin Guo and Zhengchao Yuan and Jie Cui and Yihong Shen and Pengfei Cai and Yujie Chen and Mok, {Tsz Ngai} and Mohamed EL-Newehy and Hany EL-Hamshary and Binbin Sun and Jieruo Li and Xiumei Mo",

year = "2024",

month = feb,

doi = "10.1016/j.apmt.2024.102070",

language = "English",

volume = "36",

journal = "Applied Materials Today",

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TY - JOUR

T1 - Induction of macrophage polarization by electrospun nano-yarn containing naproxen sodium to promote tendon repair

AU - Yu, Xiao

AU - Shen, Guiwang

AU - Yan, Jiujiu

AU - Guo, Wanxin

AU - Yuan, Zhengchao

AU - Cui, Jie

AU - Shen, Yihong

AU - Cai, Pengfei

AU - Chen, Yujie

AU - Mok, Tsz Ngai

AU - EL-Newehy, Mohamed

AU - EL-Hamshary, Hany

AU - Sun, Binbin

AU - Li, Jieruo

AU - Mo, Xiumei

PY - 2024/2

Y1 - 2024/2

N2 - Excessive inflammatory response can lead to failure of the tendon repair surgery. Tendon substitutes that can effectively balance inflammatory responses and have sufficient mechanical properties are one of the key factors in promoting repair. In this study, the nanofibers containing the naproxen sodium were attached to polylactic acid micron yarn by electrospinning to obtain double-layer core-spun yarn (DY). The DY was knitted into a tendon tissue engineering scaffold with sufficient mechanical properties. This study confirmed the optimal loading concentration of naproxen sodium. The results in vitro and in vivo indicated that sustained-release naproxen sodium in scaffolds could effectively inhibit the rapid proliferation of foreign fibroblasts, accelerate the polarization of macrophages, reduce the inflammatory response, and promote tendon tissue repair. This study provides a new scaffold for tendon tissue engineering that not only serves as a substitute for tendon repair, but also serves as an anti-inflammatory agent to better promote the repair process. © 2024 Elsevier Ltd.

AB - Excessive inflammatory response can lead to failure of the tendon repair surgery. Tendon substitutes that can effectively balance inflammatory responses and have sufficient mechanical properties are one of the key factors in promoting repair. In this study, the nanofibers containing the naproxen sodium were attached to polylactic acid micron yarn by electrospinning to obtain double-layer core-spun yarn (DY). The DY was knitted into a tendon tissue engineering scaffold with sufficient mechanical properties. This study confirmed the optimal loading concentration of naproxen sodium. The results in vitro and in vivo indicated that sustained-release naproxen sodium in scaffolds could effectively inhibit the rapid proliferation of foreign fibroblasts, accelerate the polarization of macrophages, reduce the inflammatory response, and promote tendon tissue repair. This study provides a new scaffold for tendon tissue engineering that not only serves as a substitute for tendon repair, but also serves as an anti-inflammatory agent to better promote the repair process. © 2024 Elsevier Ltd.

KW - Anti-inflammatory

KW - Electrospinning

KW - Naproxen sodium

KW - Tendon repair

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U2 - 10.1016/j.apmt.2024.102070

DO - 10.1016/j.apmt.2024.102070

M3 - RGC 21 - Publication in refereed journal

AN - SCOPUS:85182911628

SN - 2352-9407

VL - 36

JO - Applied Materials Today

JF - Applied Materials Today

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ER -

Induction of macrophage polarization by electrospun nano-yarn containing naproxen sodium to promote tendon repair

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