Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles

Chaiyaporn Kuwentrai; Jinming Yu; Bao-zhong Zhang; Ye-fan Hu; Ying Dou; Hua-rui Gong; Jian-Dong Huang; Chenjie Xu

doi:10.1155/2021/5531220

Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles

Chaiyaporn Kuwentrai, Jinming Yu, Bao-zhong Zhang, Ye-fan Hu, Ying Dou, Hua-rui Gong, Jian-Dong Huang^*, Chenjie Xu^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

13 Citations (Scopus)

45 Downloads (CityUHK Scholars)

Abstract

The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.

Original language	English
Article number	5531220
Number of pages	8
Journal	Journal of Immunology Research
Volume	2021
Online published	18 May 2021
DOIs	https://doi.org/10.1155/2021/5531220
Publication status	Published - 2021

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1155/2021/5531220

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@article{964d127eefdc4396b376d87602f559a6,

title = "Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles",

abstract = "The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.",

author = "Chaiyaporn Kuwentrai and Jinming Yu and Bao-zhong Zhang and Ye-fan Hu and Ying Dou and Hua-rui Gong and Jian-Dong Huang and Chenjie Xu",

year = "2021",

doi = "10.1155/2021/5531220",

language = "English",

volume = "2021",

journal = "Journal of Immunology Research",

issn = "2314-8861",

publisher = "John Wiley & Sons",

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TY - JOUR

T1 - Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles

AU - Kuwentrai, Chaiyaporn

AU - Yu, Jinming

AU - Zhang, Bao-zhong

AU - Hu, Ye-fan

AU - Dou, Ying

AU - Gong, Hua-rui

AU - Huang, Jian-Dong

AU - Xu, Chenjie

PY - 2021

Y1 - 2021

N2 - The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.

AB - The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.

UR - http://www.scopus.com/inward/record.url?scp=85107179393&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85107179393&origin=recordpage

U2 - 10.1155/2021/5531220

DO - 10.1155/2021/5531220

M3 - RGC 21 - Publication in refereed journal

C2 - 34056008

SN - 2314-8861

VL - 2021

JO - Journal of Immunology Research

JF - Journal of Immunology Research

M1 - 5531220

ER -

Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles

Abstract

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UN SDGs

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GRF: Development of Highly Swellable Microneedle Skin Patches for Skin Interstitial Fluid Sampling and In Situ Transdermal Biosensing

NSFC: Nanometallic Conductive Composite-hydrogel Core-shell Microneedle Skin Patch for Real-time Monitoring Physiological Signals

Cite this

Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles

Abstract

Publisher's Copyright Statement

RGC Funding Information

UN SDGs

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

GRF: Development of Highly Swellable Microneedle Skin Patches for Skin Interstitial Fluid Sampling and In Situ Transdermal Biosensing

NSFC: Nanometallic Conductive Composite-hydrogel Core-shell Microneedle Skin Patch for Real-time Monitoring Physiological Signals

Cite this