Incremental prognostic value of ADC histogram analysis in patients with high-risk prostate cancer receiving adjuvant hormonal therapy after radical prostatectomy

Purpose: To investigate the incremental prognostic value of preoperative apparent diffusion coefficient (ADC) histogram analysis in patients with high-risk prostate cancer (PCa) who received adjuvant hormonal therapy (AHT) after radical prostatectomy (RP).
Methods: Sixty-two PCa patients in line with the criteria were enrolled in this study. The 10^th, 50^th, and 90^th percentiles of ADC (ADC₁₀, ADC₅₀, ADC₉₀), the mean value of ADC (ADC_mean), kurtosis, and skewness were obtained from the whole-lesion ADC histogram. The Kaplan–Meier method and Cox regression analysis were used to analyze the relationship between biochemical recurrence-free survival (BCR-fs) and ADC parameters and other clinicopathological factors. Prognostic models were constructed with and without ADC parameters.
Results: The median follow-up time was 53.4 months (range, 41.1-79.3 months). BCR was found in 19 (30.6%) patients. Kaplan−Meier curves showed that lower ADC_mean, ADC₁₀, ADC₅₀, and ADC₉₀ and higher kurtosis could predict poorer BCR-fs (all p<0.05). After adjusting for clinical parameters, ADC₅₀ and kurtosis remained independent prognostic factors for BCR-fs (HR: 0.172, 95% CI: 0.055-0.541, p=0.003; HR: 7.058, 95% CI: 2.288-21.773, p=0.001, respectively). By adding ADC parameters to the clinical model, the C index and diagnostic accuracy for the 24- and 36-month BCR-fs were improved. Conclusion: ADC histogram analysis has incremental prognostic value in patients with high-risk PCa who received AHT after RP. Combining ADC₅₀, kurtosis and clinical parameters can improve the accuracy of BCR-fs prediction.
Copyright © 2023 He, Zhang, Li, Yuan, Liang, Zhang, Xie, Xiao, Li, Meng and Li.