IncHI2 Plasmids Are the Key Vectors Responsible for oqxAB Transmission among Salmonella Species

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

16 Scopus Citations
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Author(s)

  • Marcus Ho-yin Wong
  • Edward Wai-chi Chan
  • Liqi Xie
  • Ruichao Li
  • Sheng Chen

Detail(s)

Original languageEnglish
Pages (from-to)6911-6915
Journal / PublicationAntimicrobial Agents and Chemotherapy
Volume60
Issue number11
Online published21 Oct 2016
Publication statusPublished - Nov 2016
Externally publishedYes

Abstract

This study reported and analyzed the complete sequences of two oqxAB-bearing IncHI2 plasmids harbored by a clinical Salmonella enterica serovar Typhimurium strain and an S. Indiana strain of animal origin, respectively. In particular, pA3T recovered from S. Indiana comprised the resistance determinants oqxAB, aac(6′)Ib-cr, fosA3, and blaCTX-M-14. Further genetic screening of 63 oqxAB-positive Salmonella isolates revealed that the majority carried IncHI2 plasmids, confirming that such plasmids play a pivotal role in dissemination of oqxAB in Salmonella spp.

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