IncFII Conjugative Plasmid-Mediated Transmission of blaNDM-1 Elements among Animal-Borne Escherichia coli Strains

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Dachuan Lin
  • Ruichao Li
  • Kaichao Chen
  • Edward Wai-Chi Chan

Detail(s)

Original languageEnglish
Article numbere02285-16
Journal / PublicationAntimicrobial Agents and Chemotherapy
Volume61
Issue number1
Online published27 Dec 2016
Publication statusPublished - Jan 2017
Externally publishedYes

Abstract

This study aims to investigate the prevalence and transmission dynamics of the blaNDM-1 gene in animal Escherichia coli strains. Two IncFII blaNDM-1-encoding plasmids with only minor structural variation in the MDR region, pHNEC46-NDM and pHNEC55-NDM, were found to be responsible for the transmission of blaNDM-1 in these strains. The blaNDM-1 gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure.

Research Area(s)

  • Animal, blaNDM-1, Escherichia coli, IncFII, Plasmid sequence, Transposons

Citation Format(s)