Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Xiaojun Liu
  • Xiusheng Chu
  • Ding Li

Detail(s)

Original languageEnglish
Pages (from-to)3877-3880
Journal / PublicationOrganic Letters
Volume9
Issue number20
Publication statusPublished - 27 Sep 2007

Abstract

Selective inactivation of cytosolic thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity was studied, which provides an example for rationally developing mechanism-based inhibitors based on a side activity of the enzyme, and may become a supplemental method for better treatment of cardiovascular disease and cancer. © 2007 American Chemical Society.

Citation Format(s)

Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity. / Wu, Long; Zeng, Jia; Deng, Guisheng; Guo, Fei; Li, Nan; Liu, Xiaojun; Chu, Xiusheng; Li, Ding.

In: Organic Letters, Vol. 9, No. 20, 27.09.2007, p. 3877-3880.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal