Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity

Long Wu; Jia Zeng; Guisheng Deng; Fei Guo; Nan Li; Xiaojun Liu; Xiusheng Chu; Ding Li

doi:10.1021/ol0712677

Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity

Long Wu
, Jia Zeng
, Guisheng Deng
, Fei Guo
, Nan Li
, Xiaojun Liu
, Xiusheng Chu
, Ding Li

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

5 Citations (Scopus)

Abstract

Selective inactivation of cytosolic thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity was studied, which provides an example for rationally developing mechanism-based inhibitors based on a side activity of the enzyme, and may become a supplemental method for better treatment of cardiovascular disease and cancer. © 2007 American Chemical Society.

Original language	English
Pages (from-to)	3877-3880
Journal	Organic Letters
Volume	9
Issue number	20
DOIs	https://doi.org/10.1021/ol0712677
Publication status	Published - 27 Sept 2007

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title = "Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity",

abstract = "Selective inactivation of cytosolic thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity was studied, which provides an example for rationally developing mechanism-based inhibitors based on a side activity of the enzyme, and may become a supplemental method for better treatment of cardiovascular disease and cancer. {\textcopyright} 2007 American Chemical Society.",

author = "Long Wu and Jia Zeng and Guisheng Deng and Fei Guo and Nan Li and Xiaojun Liu and Xiusheng Chu and Ding Li",

year = "2007",

month = sep,

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language = "English",

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journal = "Organic Letters",

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TY - JOUR

T1 - Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity

AU - Wu, Long

AU - Zeng, Jia

AU - Deng, Guisheng

AU - Guo, Fei

AU - Li, Nan

AU - Liu, Xiaojun

AU - Chu, Xiusheng

AU - Li, Ding

PY - 2007/9/27

Y1 - 2007/9/27

N2 - Selective inactivation of cytosolic thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity was studied, which provides an example for rationally developing mechanism-based inhibitors based on a side activity of the enzyme, and may become a supplemental method for better treatment of cardiovascular disease and cancer. © 2007 American Chemical Society.

AB - Selective inactivation of cytosolic thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity was studied, which provides an example for rationally developing mechanism-based inhibitors based on a side activity of the enzyme, and may become a supplemental method for better treatment of cardiovascular disease and cancer. © 2007 American Chemical Society.

UR - https://www.scopus.com/pages/publications/35048855939

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-35048855939&origin=recordpage

U2 - 10.1021/ol0712677

DO - 10.1021/ol0712677

M3 - RGC 21 - Publication in refereed journal

C2 - 17764185

SN - 1523-7060

VL - 9

SP - 3877

EP - 3880

JO - Organic Letters

JF - Organic Letters

IS - 20

ER -

Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity

Abstract

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