In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent

Tao Zhang; Rongfeng Lan; Chi-Fai Chan; Ga-Lai Law; Wai-Kwok Wong; Ka-Leung Wong

doi:10.1073/pnas.1414499111

In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent

Tao Zhang
, Rongfeng Lan
, Chi-Fai Chan
, Ga-Lai Law
, Wai-Kwok Wong
, Ka-Leung Wong

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

87 Citations (Scopus)

Abstract

In this work, we demonstrate a modality of photodynamic therapy (PDT) through the design of our truly dual-functional - PDT and imaging - gadolinium complex (Gd-N), which can target cancer cells specifically. In the light of our design, the PDT drug can specifically localize on the anionic cell membrane of cancer cells in which its laser-excited photoemission signal can be monitored without triggering the phototoxic generation of reactive oxygen species - singlet oxygen - before due excitation. Comprehensive in vitro and in vivo studies had been conducted for the substantiation of the effectiveness of Gd-N as such a tumor-selective PDT photosensitizer. This treatment modality does initiate a new direction in the development of "precision medicine" in line with stem cell and gene therapies as tools in cancer therapy. © 2014, National Academy of Sciences. All rights reserved.

Original language	English
Pages (from-to)	E5492-E5497
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	111
Issue number	51
DOIs	https://doi.org/10.1073/pnas.1414499111
Publication status	Published - 23 Dec 2014
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This work was funded by grants from The Hong Kong Research Grants Council [Hong Kong Baptist University (HKBU) 203112], HKBU (FRG 2/12-13/002), and Hong Kong Polytechnic University Projects YL01 and GUCO8. The work was also supported by Partner State Key Laboratory of Environmental and Biological Analysis and the Strategic Development Fund of HKBU.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Gadolinium
Imaging
In vivo PDT
Survivin
Tumor recognition

RGC Funding Information

RGC-funded

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10.1073/pnas.1414499111

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abstract = "In this work, we demonstrate a modality of photodynamic therapy (PDT) through the design of our truly dual-functional - PDT and imaging - gadolinium complex (Gd-N), which can target cancer cells specifically. In the light of our design, the PDT drug can specifically localize on the anionic cell membrane of cancer cells in which its laser-excited photoemission signal can be monitored without triggering the phototoxic generation of reactive oxygen species - singlet oxygen - before due excitation. Comprehensive in vitro and in vivo studies had been conducted for the substantiation of the effectiveness of Gd-N as such a tumor-selective PDT photosensitizer. This treatment modality does initiate a new direction in the development of {"}precision medicine{"} in line with stem cell and gene therapies as tools in cancer therapy. {\textcopyright} 2014, National Academy of Sciences. All rights reserved.",

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In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent. / Zhang, Tao; Lan, Rongfeng; Chan, Chi-Fai et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 51, 23.12.2014, p. E5492-E5497.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent

AU - Zhang, Tao

AU - Lan, Rongfeng

AU - Chan, Chi-Fai

AU - Law, Ga-Lai

AU - Wong, Wai-Kwok

AU - Wong, Ka-Leung

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2014/12/23

Y1 - 2014/12/23

N2 - In this work, we demonstrate a modality of photodynamic therapy (PDT) through the design of our truly dual-functional - PDT and imaging - gadolinium complex (Gd-N), which can target cancer cells specifically. In the light of our design, the PDT drug can specifically localize on the anionic cell membrane of cancer cells in which its laser-excited photoemission signal can be monitored without triggering the phototoxic generation of reactive oxygen species - singlet oxygen - before due excitation. Comprehensive in vitro and in vivo studies had been conducted for the substantiation of the effectiveness of Gd-N as such a tumor-selective PDT photosensitizer. This treatment modality does initiate a new direction in the development of "precision medicine" in line with stem cell and gene therapies as tools in cancer therapy. © 2014, National Academy of Sciences. All rights reserved.

AB - In this work, we demonstrate a modality of photodynamic therapy (PDT) through the design of our truly dual-functional - PDT and imaging - gadolinium complex (Gd-N), which can target cancer cells specifically. In the light of our design, the PDT drug can specifically localize on the anionic cell membrane of cancer cells in which its laser-excited photoemission signal can be monitored without triggering the phototoxic generation of reactive oxygen species - singlet oxygen - before due excitation. Comprehensive in vitro and in vivo studies had been conducted for the substantiation of the effectiveness of Gd-N as such a tumor-selective PDT photosensitizer. This treatment modality does initiate a new direction in the development of "precision medicine" in line with stem cell and gene therapies as tools in cancer therapy. © 2014, National Academy of Sciences. All rights reserved.

KW - Gadolinium

KW - Imaging

KW - In vivo PDT

KW - Survivin

KW - Tumor recognition

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C2 - 25453097

SN - 0027-8424

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -

In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent

Abstract

Bibliographical note

Funding

UN SDGs

Research Keywords

RGC Funding Information

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