In Vivo Real-Time Pharmaceutical Evaluations of Near-Infrared II Fluorescent Nanomedicine Bound Polyethylene Glycol Ligands for Tumor Photothermal Ablation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

13 Scopus Citations
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Author(s)

  • Shengliang Li
  • Haoting Chen
  • Haile Liu
  • Lu Liu
  • Yuan Yuan
  • Cong Mao
  • Wei Zhang
  • Xiaodong Zhang
  • Weisheng Guo
  • Xing-Jie Liang

Detail(s)

Original languageEnglish
Pages (from-to)13681-13690
Journal / PublicationACS Nano
Volume14
Issue number10
Online published14 Sep 2020
Publication statusPublished - 27 Oct 2020

Abstract

Pharmaceutical evaluations of nanomedicines are of great significance for their further launch into industry and clinic. Near-infrared (NIR) fluorescence imaging plays essential roles in preclinical drug development by providing important insights into the biodistributions of drugs in vivo with deep tissue penetration and high spatiotemporal resolution. However, NIR-II fluorescence imaging has rarely been exploited for in vivo real-time pharmaceutical evaluations of nanomedicine. Herein, we developed a highly emissive NIR-II luminophore to establish a versatile nanoplatform to noninvasively monitor the in vivo metabolism of nanomedicines bound various polyethylene glycol (PEG) ligands in a real-time manner. An alternative D-A-D conjugated oligomer (DTTB) was synthesized to achieve NIR-II emission peaked at ∼1050 nm with high fluorescence QYs of 13.4% and a large absorption coefficient. By anchoring with the DTTB molecule, intrinsically fluorescent micelles were fabricated and bound with PEG ligands at various chain lengths. In vivo NIR-II fluorescence and photoacoustic imaging results revealed that an appropriate PEG chain length could effectively contribute to the longer blood circulation and better tumor targeting. In vivo therapeutic experiments also confirmed the optimized nanomedicines have efficient photothermal elimination of tumors and good biosafety. This work offered an alternative highly fluorescent NIR-II material and demonstrated a promising approach for real-time pharmaceutical evaluation of nanomedicine in vivo.

Research Area(s)

  • nanomedicine, NIR-II imaging, pharmaceutic behavior, photoacoustic imaging, photothermal therapy

Citation Format(s)

In Vivo Real-Time Pharmaceutical Evaluations of Near-Infrared II Fluorescent Nanomedicine Bound Polyethylene Glycol Ligands for Tumor Photothermal Ablation. / Li, Shengliang; Chen, Haoting; Liu, Haile; Liu, Lu; Yuan, Yuan; Mao, Cong; Zhang, Wei; Zhang, Xiaodong; Guo, Weisheng; Lee, Chun-Sing; Liang, Xing-Jie.

In: ACS Nano, Vol. 14, No. 10, 27.10.2020, p. 13681-13690.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review