In vivo anticoagulation of titanium oxide film coated coronary artery stent prepared by plasma immersion ion implantation and deposition

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)22_Publication in policy or professional journal

View graph of relations

Author(s)

  • N. Huang
  • Y. X. Leng
  • P. Yang
  • J. Y. Chen
  • H. Sun
  • J. Wang
  • G. J. Wan
  • A. S. Zhao

Detail(s)

Original languageEnglish
Article number5P52
Journal / PublicationIEEE International Conference on Plasma Science
Publication statusPublished - 2004
Externally publishedYes

Conference

Title31st IEEE International Conference on Plasma Science (ICOPS2004)
PlaceUnited States
CityBaltimore
Period28 June - 1 July 2004

Abstract

Application of coronary stent has successful saved thousands of patients' lives. However insufficient biocompatibility for the stent material such as stainless steel and TiNi alloy has caused the complications such as thrombogenicity and re-stenosis. Surface coatings have been suggested to decrease the thrombogenicity of metallic coronary stent. Our previous studies of Ti-O thin films synthesized using plasma immersion ion implantation and deposition (PIIID) have shown that Ti-O films possess superior blood compatibility to the conventional clinically-applied cardiovascular biomaterials. In the work described here we focused our attention on the in vivo anticoagulation behavior of Ti-O thin film coated coronary stent. Coronary stent made from stainless steel were coated by Ti-O thin film and then were implanted into rabbits ventral aoeta for different periods from 4 weeks to 20 weeks under conditions of no anticoagulant. The results of the implantations showed no thrombus formation on the surfaces of the Ti-O thin film coated stents, although serious coagulation had occurred on the surfaces of unmodified stent.

Citation Format(s)

In vivo anticoagulation of titanium oxide film coated coronary artery stent prepared by plasma immersion ion implantation and deposition. / Huang, N.; Leng, Y. X.; Yang, P.; Chen, J. Y.; Sun, H.; Wang, J.; Wan, G. J.; Zhao, A. S.; Chu, P. K.

In: IEEE International Conference on Plasma Science, 2004.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)22_Publication in policy or professional journal