In vitro profiling of endocrine disrupting potency of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogs (HO-PBDEs)

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Michael H.W. Lam
  • John P. Giesy
  • Xiaowei Zhang
  • Hongxia Yu

Detail(s)

Original languageEnglish
Pages (from-to)287-296
Journal / PublicationMarine Pollution Bulletin
Volume63
Issue number5-12
Publication statusPublished - 2011

Abstract

The potential of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and its related hydroxylated analogs (2′-HO-BDE28, 6-HO-BDE47, 4′-HO-BDE17, and 4′-HO-BDE49) to modulate estrogen/thyroid/androgen receptor-(ER, TR, AR), mediated responses were investigated by use of reporter gene assays. Exposure to 1 or 10. μM, 4′-HO-BDE17 significantly up-regulated expression of Luc, whereas other four chemicals did not induce Luc expression under control of the ER. Anti-estrogenic potency was observed for 4′-HO-BDE17 (IC50 = 1.14. μM). >. 6-HO-BDE47 (IC50 = 2.65. μM). >. 2′-HO-BDE28 (IC50 = 9.49. μM). >. BDE47 (IC50 = 21.11. μM). No anti-estrogenic effect of 4′-HO-BDE49 was observed. Both 4′-HO-BDE17, 4′-HO-BDE49 resulted in greater responses of Luc expression induced by T3. BDE47, 2′-HO-BDE28, 6-HO-BDE47 did not show any effect on the expression of Luc induced by 5. nM T3. 6-HO-BDE47 (IC50 = 0.34. μM). >. 4′-HO-BDE17 (IC50 = 1.41. μM). >. BDE47 (IC50 = 3.83. μM). >. 2′-HO-BDE28 (IC50 = 29.22. μM) exhibited anti-androgenic potency, while 4′-HO-BDE49 did not show androgenic transcriptional activity. © 2011.

Research Area(s)

  • BDE47, Endocrine disruption, Metabolite, Receptor reporter gene assay

Citation Format(s)

In vitro profiling of endocrine disrupting potency of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogs (HO-PBDEs). / Liu, Hongling; Hu, Wei; Sun, Hong; Shen, Ouxi; Wang, Xinru; Lam, Michael H.W.; Giesy, John P.; Zhang, Xiaowei; Yu, Hongxia.

In: Marine Pollution Bulletin, Vol. 63, No. 5-12, 2011, p. 287-296.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review