In vitro profiling of endocrine disrupting potency of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogs (HO-PBDEs)

Hongling Liu; Wei Hu; Hong Sun; Ouxi Shen; Xinru Wang; Michael H.W. Lam; John P. Giesy; Xiaowei Zhang; Hongxia Yu

doi:10.1016/j.marpolbul.2011.04.019

In vitro profiling of endocrine disrupting potency of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogs (HO-PBDEs)

Hongling Liu
, Wei Hu
, Hong Sun
, Ouxi Shen
, Xinru Wang
, Michael H.W. Lam
, John P. Giesy
, Xiaowei Zhang
, Hongxia Yu

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

43 Citations (Scopus)

Abstract

The potential of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and its related hydroxylated analogs (2′-HO-BDE28, 6-HO-BDE47, 4′-HO-BDE17, and 4′-HO-BDE49) to modulate estrogen/thyroid/androgen receptor-(ER, TR, AR), mediated responses were investigated by use of reporter gene assays. Exposure to 1 or 10. μM, 4′-HO-BDE17 significantly up-regulated expression of Luc, whereas other four chemicals did not induce Luc expression under control of the ER. Anti-estrogenic potency was observed for 4′-HO-BDE17 (IC50 = 1.14. μM). >. 6-HO-BDE47 (IC50 = 2.65. μM). >. 2′-HO-BDE28 (IC50 = 9.49. μM). >. BDE47 (IC50 = 21.11. μM). No anti-estrogenic effect of 4′-HO-BDE49 was observed. Both 4′-HO-BDE17, 4′-HO-BDE49 resulted in greater responses of Luc expression induced by T3. BDE47, 2′-HO-BDE28, 6-HO-BDE47 did not show any effect on the expression of Luc induced by 5. nM T3. 6-HO-BDE47 (IC50 = 0.34. μM). >. 4′-HO-BDE17 (IC50 = 1.41. μM). >. BDE47 (IC50 = 3.83. μM). >. 2′-HO-BDE28 (IC50 = 29.22. μM) exhibited anti-androgenic potency, while 4′-HO-BDE49 did not show androgenic transcriptional activity. © 2011.

Original language	English
Pages (from-to)	287-296
Journal	Marine Pollution Bulletin
Volume	63
Issue number	5-12
DOIs	https://doi.org/10.1016/j.marpolbul.2011.04.019
Publication status	Published - 2011

Research Keywords

BDE47
Endocrine disruption
Metabolite
Receptor reporter gene assay

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10.1016/j.marpolbul.2011.04.019

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title = "In vitro profiling of endocrine disrupting potency of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogs (HO-PBDEs)",

abstract = "The potential of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and its related hydroxylated analogs (2′-HO-BDE28, 6-HO-BDE47, 4′-HO-BDE17, and 4′-HO-BDE49) to modulate estrogen/thyroid/androgen receptor-(ER, TR, AR), mediated responses were investigated by use of reporter gene assays. Exposure to 1 or 10. μM, 4′-HO-BDE17 significantly up-regulated expression of Luc, whereas other four chemicals did not induce Luc expression under control of the ER. Anti-estrogenic potency was observed for 4′-HO-BDE17 (IC50 = 1.14. μM). >. 6-HO-BDE47 (IC50 = 2.65. μM). >. 2′-HO-BDE28 (IC50 = 9.49. μM). >. BDE47 (IC50 = 21.11. μM). No anti-estrogenic effect of 4′-HO-BDE49 was observed. Both 4′-HO-BDE17, 4′-HO-BDE49 resulted in greater responses of Luc expression induced by T3. BDE47, 2′-HO-BDE28, 6-HO-BDE47 did not show any effect on the expression of Luc induced by 5. nM T3. 6-HO-BDE47 (IC50 = 0.34. μM). >. 4′-HO-BDE17 (IC50 = 1.41. μM). >. BDE47 (IC50 = 3.83. μM). >. 2′-HO-BDE28 (IC50 = 29.22. μM) exhibited anti-androgenic potency, while 4′-HO-BDE49 did not show androgenic transcriptional activity. {\textcopyright} 2011.",

keywords = "BDE47, Endocrine disruption, Metabolite, Receptor reporter gene assay",

author = "Hongling Liu and Wei Hu and Hong Sun and Ouxi Shen and Xinru Wang and Lam, \{Michael H.W.\} and Giesy, \{John P.\} and Xiaowei Zhang and Hongxia Yu",

year = "2011",

doi = "10.1016/j.marpolbul.2011.04.019",

language = "English",

volume = "63",

pages = "287--296",

journal = "Marine Pollution Bulletin",

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T1 - In vitro profiling of endocrine disrupting potency of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogs (HO-PBDEs)

AU - Liu, Hongling

AU - Hu, Wei

AU - Sun, Hong

AU - Shen, Ouxi

AU - Wang, Xinru

AU - Lam, Michael H.W.

AU - Giesy, John P.

AU - Zhang, Xiaowei

AU - Yu, Hongxia

PY - 2011

Y1 - 2011

N2 - The potential of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and its related hydroxylated analogs (2′-HO-BDE28, 6-HO-BDE47, 4′-HO-BDE17, and 4′-HO-BDE49) to modulate estrogen/thyroid/androgen receptor-(ER, TR, AR), mediated responses were investigated by use of reporter gene assays. Exposure to 1 or 10. μM, 4′-HO-BDE17 significantly up-regulated expression of Luc, whereas other four chemicals did not induce Luc expression under control of the ER. Anti-estrogenic potency was observed for 4′-HO-BDE17 (IC50 = 1.14. μM). >. 6-HO-BDE47 (IC50 = 2.65. μM). >. 2′-HO-BDE28 (IC50 = 9.49. μM). >. BDE47 (IC50 = 21.11. μM). No anti-estrogenic effect of 4′-HO-BDE49 was observed. Both 4′-HO-BDE17, 4′-HO-BDE49 resulted in greater responses of Luc expression induced by T3. BDE47, 2′-HO-BDE28, 6-HO-BDE47 did not show any effect on the expression of Luc induced by 5. nM T3. 6-HO-BDE47 (IC50 = 0.34. μM). >. 4′-HO-BDE17 (IC50 = 1.41. μM). >. BDE47 (IC50 = 3.83. μM). >. 2′-HO-BDE28 (IC50 = 29.22. μM) exhibited anti-androgenic potency, while 4′-HO-BDE49 did not show androgenic transcriptional activity. © 2011.

AB - The potential of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and its related hydroxylated analogs (2′-HO-BDE28, 6-HO-BDE47, 4′-HO-BDE17, and 4′-HO-BDE49) to modulate estrogen/thyroid/androgen receptor-(ER, TR, AR), mediated responses were investigated by use of reporter gene assays. Exposure to 1 or 10. μM, 4′-HO-BDE17 significantly up-regulated expression of Luc, whereas other four chemicals did not induce Luc expression under control of the ER. Anti-estrogenic potency was observed for 4′-HO-BDE17 (IC50 = 1.14. μM). >. 6-HO-BDE47 (IC50 = 2.65. μM). >. 2′-HO-BDE28 (IC50 = 9.49. μM). >. BDE47 (IC50 = 21.11. μM). No anti-estrogenic effect of 4′-HO-BDE49 was observed. Both 4′-HO-BDE17, 4′-HO-BDE49 resulted in greater responses of Luc expression induced by T3. BDE47, 2′-HO-BDE28, 6-HO-BDE47 did not show any effect on the expression of Luc induced by 5. nM T3. 6-HO-BDE47 (IC50 = 0.34. μM). >. 4′-HO-BDE17 (IC50 = 1.41. μM). >. BDE47 (IC50 = 3.83. μM). >. 2′-HO-BDE28 (IC50 = 29.22. μM) exhibited anti-androgenic potency, while 4′-HO-BDE49 did not show androgenic transcriptional activity. © 2011.

KW - BDE47

KW - Endocrine disruption

KW - Metabolite

KW - Receptor reporter gene assay

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U2 - 10.1016/j.marpolbul.2011.04.019

DO - 10.1016/j.marpolbul.2011.04.019

M3 - RGC 21 - Publication in refereed journal

C2 - 21737105

SN - 0025-326X

VL - 63

SP - 287

EP - 296

JO - Marine Pollution Bulletin

JF - Marine Pollution Bulletin

IS - 5-12

ER -

In vitro profiling of endocrine disrupting potency of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogs (HO-PBDEs)

Abstract

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