In vitro imaging and Human Serum Albumin responsive dimeric lanthanide DO3A complex

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Yuen On Fung
  • Wanqing Wu
  • Chi-Tung Yeung
  • Kenny Kam-Cheng Wong
  • Wai-Sum Lo
  • Ga-Lai Law
  • Ka-Leung Wong
  • Chi-Sing Lee
  • Wing-Tak Wong

Detail(s)

Original languageEnglish
Pages (from-to)5517-5525
Journal / PublicationInorganic Chemistry
Volume50
Issue number12
Publication statusPublished - 20 Jun 2011
Externally publishedYes

Abstract

Two series of dimeric DO3A (1,4,7,10-tetraazacyclodecane-1,4,7-triacetate) lanthanide complexes (LnL1-LnL2, Ln = Eu, Gd, and Tb) have been synthesized with two different bridged chromophores. The X-ray structures of dimeric LnL1 (Ln = Gd and Tb) complexes show that each metal ion has nine coordination numbers with eight directly bound donor atoms of the ligand and one oxygen donor from the water molecule. Photophysical measurements indicate that the bridged antenna in LnL2 gives a higher efficiency than that of LnL1 and is responsive to the protein Human Serum Albumin (HSA), giving an f-f luminescence signal enhancement with a binding constant log K = 4.84. In vitro imaging of EuL1 and EuL2 in HeLa cells has been recorded, and EuL2 has demonstrated a higher rate of cellular uptake and low cytotoxicity (IC50 = 3 mM). © 2011 American Chemical Society.

Citation Format(s)

In vitro imaging and Human Serum Albumin responsive dimeric lanthanide DO3A complex. / Fung, Yuen On; Wu, Wanqing; Yeung, Chi-Tung; Kong, Hoi-Kuan; Wong, Kenny Kam-Cheng; Lo, Wai-Sum; Law, Ga-Lai; Wong, Ka-Leung; Lau, Chi-Kong; Lee, Chi-Sing; Wong, Wing-Tak.

In: Inorganic Chemistry, Vol. 50, No. 12, 20.06.2011, p. 5517-5525.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review