TY - JOUR
T1 - In vitro imaging and Human Serum Albumin responsive dimeric lanthanide DO3A complex
AU - Fung, Yuen On
AU - Wu, Wanqing
AU - Yeung, Chi-Tung
AU - Kong, Hoi-Kuan
AU - Wong, Kenny Kam-Cheng
AU - Lo, Wai-Sum
AU - Law, Ga-Lai
AU - Wong, Ka-Leung
AU - Lau, Chi-Kong
AU - Lee, Chi-Sing
AU - Wong, Wing-Tak
PY - 2011/6/20
Y1 - 2011/6/20
N2 - Two series of dimeric DO3A (1,4,7,10-tetraazacyclodecane-1,4,7-triacetate) lanthanide complexes (LnL1-LnL2, Ln = Eu, Gd, and Tb) have been synthesized with two different bridged chromophores. The X-ray structures of dimeric LnL1 (Ln = Gd and Tb) complexes show that each metal ion has nine coordination numbers with eight directly bound donor atoms of the ligand and one oxygen donor from the water molecule. Photophysical measurements indicate that the bridged antenna in LnL2 gives a higher efficiency than that of LnL1 and is responsive to the protein Human Serum Albumin (HSA), giving an f-f luminescence signal enhancement with a binding constant log K = 4.84. In vitro imaging of EuL1 and EuL2 in HeLa cells has been recorded, and EuL2 has demonstrated a higher rate of cellular uptake and low cytotoxicity (IC50 = 3 mM). © 2011 American Chemical Society.
AB - Two series of dimeric DO3A (1,4,7,10-tetraazacyclodecane-1,4,7-triacetate) lanthanide complexes (LnL1-LnL2, Ln = Eu, Gd, and Tb) have been synthesized with two different bridged chromophores. The X-ray structures of dimeric LnL1 (Ln = Gd and Tb) complexes show that each metal ion has nine coordination numbers with eight directly bound donor atoms of the ligand and one oxygen donor from the water molecule. Photophysical measurements indicate that the bridged antenna in LnL2 gives a higher efficiency than that of LnL1 and is responsive to the protein Human Serum Albumin (HSA), giving an f-f luminescence signal enhancement with a binding constant log K = 4.84. In vitro imaging of EuL1 and EuL2 in HeLa cells has been recorded, and EuL2 has demonstrated a higher rate of cellular uptake and low cytotoxicity (IC50 = 3 mM). © 2011 American Chemical Society.
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U2 - 10.1021/ic2004672
DO - 10.1021/ic2004672
M3 - RGC 21 - Publication in refereed journal
C2 - 21591737
SN - 0020-1669
VL - 50
SP - 5517
EP - 5525
JO - Inorganic Chemistry
JF - Inorganic Chemistry
IS - 12
ER -