In vitro and in vivo anti-biofilm effects of silver nanoparticles immobilized on titanium

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

183 Scopus Citations
View graph of relations

Author(s)

  • Hui Qin
  • Huiliang Cao
  • Yaochao Zhao
  • Cheng Zhu
  • Tao Cheng
  • Qiaojie Wang
  • Xiaochun Peng
  • Mengqi Cheng
  • Jiaxin Wang
  • Guodong Jin
  • Yao Jiang
  • Xianlong Zhang
  • Xuanyong Liu

Detail(s)

Original languageEnglish
Pages (from-to)9114-9125
Journal / PublicationBiomaterials
Volume35
Issue number33
Online published8 Aug 2014
Publication statusPublished - Nov 2014

Abstract

Prevention of periprosthetic infection (PPI) by inhibiting biofilm formation on prostheses is crucial to orthopedic surgery. In this work, silver nanoparticles (Ag NPs) are fabricated in situ and immobilized on titanium by silver plasma immersion ion implantation (PIII). The anti-biofilm activity rendered by the immobilized Ag NPs is assessed using Staphylococcus epidermidis, a biofilm producing strain, invitro and invivo. The immobilized Ag NPs show no apparent cytotoxicity but reduce biofilm formation invitro by inhibiting bacteria adhesion and icaAD transcription. The immobilized Ag NPs offer a good defense against multiple cycles of bacteria attack invitro, and the mechanism is independent of silver release. Radiographic assessment, microbiological cultures, and histopathological results demonstrate the ability of the functionalized surface against bacterial infection to reduce the risk of implant-associated PPI. © 2014 Elsevier Ltd.

Research Area(s)

  • Biofilm, Cytotoxicity, Plasma immersion ion implantation, Silver nanoparticles, Titanium

Citation Format(s)

In vitro and in vivo anti-biofilm effects of silver nanoparticles immobilized on titanium. / Qin, Hui; Cao, Huiliang; Zhao, Yaochao; Zhu, Cheng; Cheng, Tao; Wang, Qiaojie; Peng, Xiaochun; Cheng, Mengqi; Wang, Jiaxin; Jin, Guodong; Jiang, Yao; Zhang, Xianlong; Liu, Xuanyong; Chu, Paul K.

In: Biomaterials, Vol. 35, No. 33, 11.2014, p. 9114-9125.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review