In vitro and in vivo antibacterial performance of Zr & O PIII magnesium alloys with high concentration of oxygen vacancies

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
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Author(s)

  • Tao Liang
  • Lilan Zeng
  • Yunzhu Shi
  • Haobo Pan
  • Kelvin W.K. Yeung
  • Ying Zhao

Detail(s)

Original languageEnglish
Pages (from-to)3049-3061
Journal / PublicationBioactive Materials
Volume6
Issue number10
Online published9 Mar 2021
Publication statusPublished - Oct 2021

Link(s)

Abstract

The effects of dual Zr and O plasma immersion ion implantation (Zr & O PIII) on antibacterial properties of ZK60 Mg alloys are systematically investigated. The results show that a hydrophobic, smooth, and ZrO2-containing graded film is formed. Electrochemical assessment shows that the corrosion rate of the plasma-treated Mg alloy decreases and the decreased degradation rate is attributed to the protection rendered by the surface oxide. In vitro and in vivo antibacterial tests reveal Zr & O PIII ZK60 presents higher antibacterial rate compared to Zr PIII ZK60 and untreated control. The hydrophobic and smooth surface suppresses bacterial adhesion. High concentration of oxygen vacancies in the surface films are determined by X-ray photoelectron spectroscopy (XPS), UV–vis diffuse reflectance spectra (UV–vis DRS) and electron paramagnetic resonance (EPR) and involved in the production of reactive oxygen species (ROS). The higher level of ROS expression inhibits biofilm formation by down-regulating the expression of icaADBC genes but up-regulating the expression of icaR gene. In addition, Zr & O PIII improves cell viability and initial cell adhesion confirming good cytocompatibility. Dual Zr & O PIII is a simple and practical means to expedite clinical acceptance of biodegradable magnesium alloys.

Research Area(s)

  • Antibacterial property, Degradation, Magnesium alloy, Plasma immersion ion implantation, ZrO2

Citation Format(s)

In vitro and in vivo antibacterial performance of Zr & O PIII magnesium alloys with high concentration of oxygen vacancies. / Liang, Tao; Zeng, Lilan; Shi, Yunzhu; Pan, Haobo; Chu, Paul K.; Yeung, Kelvin W.K.; Zhao, Ying.

In: Bioactive Materials, Vol. 6, No. 10, 10.2021, p. 3049-3061.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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