In situ plasma fabrication of ceramic-like structure on polymeric implant with enhanced surface hardness, cytocompatibility and antibacterial capability

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jun Liu
  • Wei Zhang
  • Haigang Shi
  • Kun Yang
  • Gexia Wang
  • Pingli Wang
  • Junhui Ji

Detail(s)

Original languageEnglish
Pages (from-to)1102-1112
Journal / PublicationJournal of Biomedical Materials Research - Part A
Volume104
Issue number5
Publication statusPublished - 1 May 2016

Abstract

Polymeric materials are commonly found in orthopedic implants due to their unique mechanical properties and biocompatibility but the poor surface hardness and bacterial infection hamper many biomedical applications. In this study, a ceramic-like surface structure doped with silver is produced by successive plasma implantation of silicon (Si) and silver (Ag) into the polyamine 66 (PA66) substrate. Not only the surface hardness and elastic modulus are greatly enhanced due to the partial surface carbonization and the ceramic-like structure produced by the reaction between energetic Si and the carbon chain of PA66, but also the antibacterial activity is improved because of the combined effects rendered by Ag and SiC structure. Furthermore, the modified materials which exhibit good cytocompatibility upregulate bone-related genes and proteins expressions of the contacted bone mesenchymal stem cells (BMSCs). For the first time, it explores out that BMSCs osteogenesis on the antibacterial ceramic-like structure is mediated via the iNOS and nNOS signal pathways. The results reveal that in situ plasma fabrication of an antibacterial ceramic-like structure can endow PA66 with excellent surface hardness, cytocompatibility, as well as antibacterial capability.

Research Area(s)

  • antibacterial activity, ceramic-like structure, osteogenic activity, surface hardness

Citation Format(s)

In situ plasma fabrication of ceramic-like structure on polymeric implant with enhanced surface hardness, cytocompatibility and antibacterial capability. / Liu, Jun; Zhang, Wei; Shi, Haigang; Yang, Kun; Wang, Gexia; Wang, Pingli; Ji, Junhui; Chu, Paul K.

In: Journal of Biomedical Materials Research - Part A, Vol. 104, No. 5, 01.05.2016, p. 1102-1112.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review