Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

Jing-Xiang Zhang; Wai-Lun Chan; Chen Xie; Yan Zhou; Ho-Fai Chau; Partha Maity; George T. Harrison; Aram Amassian; Omar F. Mohammed; Peter A. Tanner; Wai-Kwok Wong; Ka-Leung Wong

doi:10.1038/s41377-019-0155-9

Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

Jing-Xiang Zhang (Co-first Author), Wai-Lun Chan (Co-first Author), Chen Xie (Co-first Author), Yan Zhou, Ho-Fai Chau, Partha Maity, George T. Harrison, Aram Amassian, Omar F. Mohammed, Peter A. Tanner^*, Wai-Kwok Wong^*, Ka-Leung Wong^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

48 Citations (Scopus)

Abstract

Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated their biomedical applications. Herein, four water-soluble homoleptic lanthanide (Ln = Gd, Er, Yb and La) sandwiches with diethylene-glycol-disubstituted porphyrins (DD) are reported, with their structures proven by both quantum chemical calculations and scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission intensity and singlet oxygen (¹O₂) quantum yields of YbDD and GdDD in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues, YbN and GdN; the brightness and luminescence lifetime in water of YbDD are greater than those of YbN. This work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates. © 2019, The Author(s).

Original language	English
Article number	46
Number of pages	10
Journal	Light: Science and Applications
Volume	8
Issue number	1
Online published	22 May 2019
DOIs	https://doi.org/10.1038/s41377-019-0155-9
Publication status	Published - 2019
Externally published	Yes

Funding

This work was supported by the Hong Kong Baptist University (HKBU), Hong Kong Research Grants Council (HKBU 12300117), and the HKBU-HKPolyU Joint Research Program (RC-ICRS/16-17/02). We thank Dr. Zhenyu Liu for his technical support in spectroscopic measurements and Professor Alex Granovsky for communication concerning the use of Firefly.

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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RGC-funded

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Zhang, J.-X., Chan, W.-L., Xie, C., Zhou, Y., Chau, H.-F., Maity, P., Harrison, G. T., Amassian, A., Mohammed, O. F., Tanner, P. A., Wong, W.-K., & Wong, K.-L. (2019). Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution. Light: Science and Applications, 8(1), Article 46. https://doi.org/10.1038/s41377-019-0155-9

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title = "Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution",

abstract = "Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated their biomedical applications. Herein, four water-soluble homoleptic lanthanide (Ln = Gd, Er, Yb and La) sandwiches with diethylene-glycol-disubstituted porphyrins (DD) are reported, with their structures proven by both quantum chemical calculations and scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission intensity and singlet oxygen (1O2) quantum yields of YbDD and GdDD in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues, YbN and GdN; the brightness and luminescence lifetime in water of YbDD are greater than those of YbN. This work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates. {\textcopyright} 2019, The Author(s).",

author = "Jing-Xiang Zhang and Wai-Lun Chan and Chen Xie and Yan Zhou and Ho-Fai Chau and Partha Maity and Harrison, {George T.} and Aram Amassian and Mohammed, {Omar F.} and Tanner, {Peter A.} and Wai-Kwok Wong and Ka-Leung Wong",

year = "2019",

doi = "10.1038/s41377-019-0155-9",

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Zhang, J-X, Chan, W-L, Xie, C, Zhou, Y, Chau, H-F, Maity, P, Harrison, GT, Amassian, A, Mohammed, OF, Tanner, PA, Wong, W-K & Wong, K-L 2019, 'Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution', Light: Science and Applications, vol. 8, no. 1, 46. https://doi.org/10.1038/s41377-019-0155-9

Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution. / Zhang, Jing-Xiang (Co-first Author); Chan, Wai-Lun (Co-first Author); Xie, Chen (Co-first Author) et al.
In: Light: Science and Applications, Vol. 8, No. 1, 46, 2019.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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AU - Zhang, Jing-Xiang

AU - Chan, Wai-Lun

AU - Xie, Chen

AU - Zhou, Yan

AU - Chau, Ho-Fai

AU - Maity, Partha

AU - Harrison, George T.

AU - Amassian, Aram

AU - Mohammed, Omar F.

AU - Tanner, Peter A.

AU - Wong, Wai-Kwok

AU - Wong, Ka-Leung

PY - 2019

Y1 - 2019

N2 - Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated their biomedical applications. Herein, four water-soluble homoleptic lanthanide (Ln = Gd, Er, Yb and La) sandwiches with diethylene-glycol-disubstituted porphyrins (DD) are reported, with their structures proven by both quantum chemical calculations and scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission intensity and singlet oxygen (1O2) quantum yields of YbDD and GdDD in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues, YbN and GdN; the brightness and luminescence lifetime in water of YbDD are greater than those of YbN. This work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates. © 2019, The Author(s).

AB - Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated their biomedical applications. Herein, four water-soluble homoleptic lanthanide (Ln = Gd, Er, Yb and La) sandwiches with diethylene-glycol-disubstituted porphyrins (DD) are reported, with their structures proven by both quantum chemical calculations and scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission intensity and singlet oxygen (1O2) quantum yields of YbDD and GdDD in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues, YbN and GdN; the brightness and luminescence lifetime in water of YbDD are greater than those of YbN. This work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates. © 2019, The Author(s).

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DO - 10.1038/s41377-019-0155-9

M3 - RGC 21 - Publication in refereed journal

SN - 2095-5545

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JF - Light: Science and Applications

IS - 1

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ER -

Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution

Abstract

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