Implication of G protein-coupled receptor 43 in intestinal inflammation : A mini-review

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

48 Scopus Citations
View graph of relations

Author(s)

  • Siyuan Chen
  • Baichuan Deng
  • Chengquan Tan
  • Jinping Deng
  • Guoqiang Zhu
  • Yulong Yin
  • Wenkai Ren

Detail(s)

Original languageEnglish
Article number1434
Journal / PublicationFrontiers in Immunology
Volume9
Issue numberJUN
Publication statusPublished - 22 Jun 2018
Externally publishedYes

Link(s)

Abstract

Short chain fatty acids (SCFAs, e.g., acetate, propionate, and butyrate) are a subset of fatty acids that are produced by gut microbiota during the fermentation of dietary fiber. They modulate different processes in the gastrointestinal tract and play various positive roles in mediating the intestinal health. Most beneficial roles of SCFAs in the gastrointestinal tract are mediated by directly activating its receptor, G protein-coupled receptor 43 (GPR43, also known as FFAR2). Various recent studies have demonstrated the role of GPR43 in intestinal inflammatory diseases, such as inflammatory bowel diseases. These SCFAs-mediated regulations of intestinal health are associated with neutrophil chemotaxis, T cell differentiation, activation, and subsequent cytokines production. Therefore, GPR43 could potentially be a drug target for intestinal inflammatory diseases. In this review, we review the current knowledge on the regulatory mechanisms associated with GPR43 in intestinal inflammation. The role of GPR43-mediated regulation of antibody responses is also discussed.

Research Area(s)

  • G protein-coupled receptor 43, Inflammation, Inflammatory bowel diseases, Intestinal microbiota, Short chain fatty acids

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Implication of G protein-coupled receptor 43 in intestinal inflammation: A mini-review. / Yang, Guan; Chen, Siyuan; Deng, Baichuan et al.
In: Frontiers in Immunology, Vol. 9, No. JUN, 1434, 22.06.2018.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

Download Statistics

No data available