Implication of G protein-coupled receptor 43 in intestinal inflammation: A mini-review

Guan Yang; Siyuan Chen; Baichuan Deng; Chengquan Tan; Jinping Deng; Guoqiang Zhu; Yulong Yin; Wenkai Ren

doi:10.3389/fimmu.2018.01434

Implication of G protein-coupled receptor 43 in intestinal inflammation: A mini-review

Guan Yang
, Siyuan Chen
, Baichuan Deng
, Chengquan Tan
, Jinping Deng^*
, Guoqiang Zhu
, Yulong Yin
, Wenkai Ren

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

82 Citations (Scopus)

35 Downloads (CityUHK Scholars)

Abstract

Short chain fatty acids (SCFAs, e.g., acetate, propionate, and butyrate) are a subset of fatty acids that are produced by gut microbiota during the fermentation of dietary fiber. They modulate different processes in the gastrointestinal tract and play various positive roles in mediating the intestinal health. Most beneficial roles of SCFAs in the gastrointestinal tract are mediated by directly activating its receptor, G protein-coupled receptor 43 (GPR43, also known as FFAR2). Various recent studies have demonstrated the role of GPR43 in intestinal inflammatory diseases, such as inflammatory bowel diseases. These SCFAs-mediated regulations of intestinal health are associated with neutrophil chemotaxis, T cell differentiation, activation, and subsequent cytokines production. Therefore, GPR43 could potentially be a drug target for intestinal inflammatory diseases. In this review, we review the current knowledge on the regulatory mechanisms associated with GPR43 in intestinal inflammation. The role of GPR43-mediated regulation of antibody responses is also discussed.

Original language	English
Article number	1434
Journal	Frontiers in Immunology
Volume	9
Issue number	JUN
DOIs	https://doi.org/10.3389/fimmu.2018.01434
Publication status	Published - 22 Jun 2018
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

G protein-coupled receptor 43
Inflammation
Inflammatory bowel diseases
Intestinal microbiota
Short chain fatty acids

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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title = "Implication of G protein-coupled receptor 43 in intestinal inflammation: A mini-review",

abstract = "Short chain fatty acids (SCFAs, e.g., acetate, propionate, and butyrate) are a subset of fatty acids that are produced by gut microbiota during the fermentation of dietary fiber. They modulate different processes in the gastrointestinal tract and play various positive roles in mediating the intestinal health. Most beneficial roles of SCFAs in the gastrointestinal tract are mediated by directly activating its receptor, G protein-coupled receptor 43 (GPR43, also known as FFAR2). Various recent studies have demonstrated the role of GPR43 in intestinal inflammatory diseases, such as inflammatory bowel diseases. These SCFAs-mediated regulations of intestinal health are associated with neutrophil chemotaxis, T cell differentiation, activation, and subsequent cytokines production. Therefore, GPR43 could potentially be a drug target for intestinal inflammatory diseases. In this review, we review the current knowledge on the regulatory mechanisms associated with GPR43 in intestinal inflammation. The role of GPR43-mediated regulation of antibody responses is also discussed.",

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T1 - Implication of G protein-coupled receptor 43 in intestinal inflammation

T2 - A mini-review

AU - Yang, Guan

AU - Chen, Siyuan

AU - Deng, Baichuan

AU - Tan, Chengquan

AU - Deng, Jinping

AU - Zhu, Guoqiang

AU - Yin, Yulong

AU - Ren, Wenkai

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2018/6/22

Y1 - 2018/6/22

N2 - Short chain fatty acids (SCFAs, e.g., acetate, propionate, and butyrate) are a subset of fatty acids that are produced by gut microbiota during the fermentation of dietary fiber. They modulate different processes in the gastrointestinal tract and play various positive roles in mediating the intestinal health. Most beneficial roles of SCFAs in the gastrointestinal tract are mediated by directly activating its receptor, G protein-coupled receptor 43 (GPR43, also known as FFAR2). Various recent studies have demonstrated the role of GPR43 in intestinal inflammatory diseases, such as inflammatory bowel diseases. These SCFAs-mediated regulations of intestinal health are associated with neutrophil chemotaxis, T cell differentiation, activation, and subsequent cytokines production. Therefore, GPR43 could potentially be a drug target for intestinal inflammatory diseases. In this review, we review the current knowledge on the regulatory mechanisms associated with GPR43 in intestinal inflammation. The role of GPR43-mediated regulation of antibody responses is also discussed.

AB - Short chain fatty acids (SCFAs, e.g., acetate, propionate, and butyrate) are a subset of fatty acids that are produced by gut microbiota during the fermentation of dietary fiber. They modulate different processes in the gastrointestinal tract and play various positive roles in mediating the intestinal health. Most beneficial roles of SCFAs in the gastrointestinal tract are mediated by directly activating its receptor, G protein-coupled receptor 43 (GPR43, also known as FFAR2). Various recent studies have demonstrated the role of GPR43 in intestinal inflammatory diseases, such as inflammatory bowel diseases. These SCFAs-mediated regulations of intestinal health are associated with neutrophil chemotaxis, T cell differentiation, activation, and subsequent cytokines production. Therefore, GPR43 could potentially be a drug target for intestinal inflammatory diseases. In this review, we review the current knowledge on the regulatory mechanisms associated with GPR43 in intestinal inflammation. The role of GPR43-mediated regulation of antibody responses is also discussed.

KW - G protein-coupled receptor 43

KW - Inflammation

KW - Inflammatory bowel diseases

KW - Intestinal microbiota

KW - Short chain fatty acids

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DO - 10.3389/fimmu.2018.01434

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SN - 1664-3224

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

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Implication of G protein-coupled receptor 43 in intestinal inflammation: A mini-review

Abstract

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Research Keywords

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