Implantable heterogeneous triboelectric nanogenerator effectively prevents denervation-induced muscle atrophy

Shuai Zhang; Renjie Tan; Ke Zhang; Shuo Meng; Xiaoyun Xu; Qi Zhang; Chuanwei Zhi; Zhuang Wang; Xinshuo Liang; Shanshan Zhu; Yanlong Tai; Jinlian Hu

doi:10.1016/j.nanoen.2024.109548

Implantable heterogeneous triboelectric nanogenerator effectively prevents denervation-induced muscle atrophy

Shuai Zhang (Co-first Author), Renjie Tan (Co-first Author), Ke Zhang, Shuo Meng, Xiaoyun Xu, Qi Zhang, Chuanwei Zhi, Zhuang Wang, Xinshuo Liang, Shanshan Zhu, Yanlong Tai, Jinlian Hu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

7 Citations (Scopus)

Abstract

Electrical stimulation (ES) is one of the most effective methods of preventing muscle atrophy. However, current electrotherapy equipment is relatively complex and inconvenient to carry, and the daily training time needs to be scheduled. Implantable flexible triboelectric nanogenerators (TENG) can realize ES and effectively avoid the above problems. Therefore, we developed a high-performance TENG with excellent biocompatibility and implanted it subcutaneously to prevent denervation-induced muscle atrophy. Moreover, molecular dynamics (MD) analysis found that the spacing of the heterogeneous film can change its dipole, which is one of the reasons for the voltage change of heterogeneous TENG (h-TENG). In addition, in vitro experiments demonstrate that h-TENG can effectively promote much more muscle cell proliferation. Furthermore, bioinformatics analysis and gene knockout methods found that h-TENG prevents muscle atrophy by upregulating the expression of the FGF6 gene. © 2024 Elsevier Ltd.

Original language	English
Article number	109548
Journal	Nano Energy
Volume	125
Online published	27 Mar 2024
DOIs	https://doi.org/10.1016/j.nanoen.2024.109548
Publication status	Published - 15 Jun 2024

Funding

The authors acknowledge the financial support from the National Natural Science Foundation of China (NSFC) with the title of "Study of High Performance Fiber to be Achieved by Mimicking the Hierarchical Structure of Spider-Silk"; grant no. 52073241 , "Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers"; grant no.51673162, "Developing Spider-Silk-Model Artificial Fibers by a Chemical Synthetic Approach"; grant no. 15201719, the Collaborative Research Fund with the title of "Fundamental Study towards Real Spider Dragline Silk Performance through Artificial Innovative Approach"; project no. 8730080 , the startup grant of CityU with the title of "Laboratory of Wearable Materials for Healthcare"; grant no. 9380116 , the contract research with the title of "Development of breathable fabrics with nano-electrospun membrane"; CityU ref.: 9231419 , and Guangdong International Technology Cooperation Project; project no. 2022A0505050058 .

Research Keywords

Electrical stimulation
FGF6
Heterogeneous films
Muscle atrophy
TENG

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COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: © 2024 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/.

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title = "Implantable heterogeneous triboelectric nanogenerator effectively prevents denervation-induced muscle atrophy",

abstract = "Electrical stimulation (ES) is one of the most effective methods of preventing muscle atrophy. However, current electrotherapy equipment is relatively complex and inconvenient to carry, and the daily training time needs to be scheduled. Implantable flexible triboelectric nanogenerators (TENG) can realize ES and effectively avoid the above problems. Therefore, we developed a high-performance TENG with excellent biocompatibility and implanted it subcutaneously to prevent denervation-induced muscle atrophy. Moreover, molecular dynamics (MD) analysis found that the spacing of the heterogeneous film can change its dipole, which is one of the reasons for the voltage change of heterogeneous TENG (h-TENG). In addition, in vitro experiments demonstrate that h-TENG can effectively promote much more muscle cell proliferation. Furthermore, bioinformatics analysis and gene knockout methods found that h-TENG prevents muscle atrophy by upregulating the expression of the FGF6 gene. {\textcopyright} 2024 Elsevier Ltd.",

keywords = "Electrical stimulation, FGF6, Heterogeneous films, Muscle atrophy, TENG",

author = "Shuai Zhang and Renjie Tan and Ke Zhang and Shuo Meng and Xiaoyun Xu and Qi Zhang and Chuanwei Zhi and Zhuang Wang and Xinshuo Liang and Shanshan Zhu and Yanlong Tai and Jinlian Hu",

year = "2024",

month = jun,

day = "15",

doi = "10.1016/j.nanoen.2024.109548",

language = "English",

volume = "125",

journal = "Nano Energy",

issn = "2211-2855",

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TY - JOUR

T1 - Implantable heterogeneous triboelectric nanogenerator effectively prevents denervation-induced muscle atrophy

AU - Zhang, Shuai

AU - Tan, Renjie

AU - Zhang, Ke

AU - Meng, Shuo

AU - Xu, Xiaoyun

AU - Zhang, Qi

AU - Zhi, Chuanwei

AU - Wang, Zhuang

AU - Liang, Xinshuo

AU - Zhu, Shanshan

AU - Tai, Yanlong

AU - Hu, Jinlian

PY - 2024/6/15

Y1 - 2024/6/15

N2 - Electrical stimulation (ES) is one of the most effective methods of preventing muscle atrophy. However, current electrotherapy equipment is relatively complex and inconvenient to carry, and the daily training time needs to be scheduled. Implantable flexible triboelectric nanogenerators (TENG) can realize ES and effectively avoid the above problems. Therefore, we developed a high-performance TENG with excellent biocompatibility and implanted it subcutaneously to prevent denervation-induced muscle atrophy. Moreover, molecular dynamics (MD) analysis found that the spacing of the heterogeneous film can change its dipole, which is one of the reasons for the voltage change of heterogeneous TENG (h-TENG). In addition, in vitro experiments demonstrate that h-TENG can effectively promote much more muscle cell proliferation. Furthermore, bioinformatics analysis and gene knockout methods found that h-TENG prevents muscle atrophy by upregulating the expression of the FGF6 gene. © 2024 Elsevier Ltd.

AB - Electrical stimulation (ES) is one of the most effective methods of preventing muscle atrophy. However, current electrotherapy equipment is relatively complex and inconvenient to carry, and the daily training time needs to be scheduled. Implantable flexible triboelectric nanogenerators (TENG) can realize ES and effectively avoid the above problems. Therefore, we developed a high-performance TENG with excellent biocompatibility and implanted it subcutaneously to prevent denervation-induced muscle atrophy. Moreover, molecular dynamics (MD) analysis found that the spacing of the heterogeneous film can change its dipole, which is one of the reasons for the voltage change of heterogeneous TENG (h-TENG). In addition, in vitro experiments demonstrate that h-TENG can effectively promote much more muscle cell proliferation. Furthermore, bioinformatics analysis and gene knockout methods found that h-TENG prevents muscle atrophy by upregulating the expression of the FGF6 gene. © 2024 Elsevier Ltd.

KW - Electrical stimulation

KW - FGF6

KW - Heterogeneous films

KW - Muscle atrophy

KW - TENG

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U2 - 10.1016/j.nanoen.2024.109548

DO - 10.1016/j.nanoen.2024.109548

M3 - RGC 21 - Publication in refereed journal

SN - 2211-2855

VL - 125

JO - Nano Energy

JF - Nano Energy

M1 - 109548

ER -

Implantable heterogeneous triboelectric nanogenerator effectively prevents denervation-induced muscle atrophy

Abstract

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Research Keywords

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CRF: Fundamental Study Towards Real Spider Dragline Silk Performance Through Artificial Innovative Approach

GRF: Developing Spider-Silk-Model Artificial Fibers by A Chemical Synthetic Approach

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Implantable heterogeneous triboelectric nanogenerator effectively prevents denervation-induced muscle atrophy

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

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CRF: Fundamental Study Towards Real Spider Dragline Silk Performance Through Artificial Innovative Approach

GRF: Developing Spider-Silk-Model Artificial Fibers by A Chemical Synthetic Approach

Cite this