Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)5944–5953
Journal / PublicationNano Letters
Volume22
Issue number14
Online published11 Jul 2022
Publication statusPublished - 27 Jul 2022

Abstract

A combined treatment using medication and electrostimulation increases its effectiveness in comparison with one treatment alone. However, the organic integration of two strategies in one miniaturized system for practical usage has seldom been reported. This article reports an implantable electronic medicine based on bioresorbable microneedle devices that is activated wirelessly for electrostimulation and sustainable delivery of anti-inflammatory drugs. The electronic medicine is composed of a radio frequency wireless power transmission system and a drug-loaded microneedle structure, all fabricated with bioresorbable materials. In a rat skeletal muscle injury model, periodic electrostimulation regulates cell behaviors and tissue regeneration while the anti-inflammatory drugs prevent inflammation, which ultimately enhance the skeletal muscle regeneration. Finally, the electronic medicine is fully bioresorbable, excluding the second surgery for device removal. © 2022 American Chemical Society.

Research Area(s)

  • electronic medicine, implantable electronics, microneedle, drug delivery, electrostimulation, ELECTRICAL-STIMULATION, TRANSIENT, DIFFERENTIATION, CORROSION, METALS, GOLD

Citation Format(s)

Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery. / Huang, Ya; Li, Hu; Hu, Tianli et al.
In: Nano Letters, Vol. 22, No. 14, 27.07.2022, p. 5944–5953.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review