Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery

Ya Huang; Hu Li; Tianli Hu; Jian Li; Chun Ki Yiu; Jingkun Zhou; Jiyu Li; Xingcan Huang; Kuanming Yao; Xiao Qiu; Yu Zhou; Dengfeng Li; Binbin Zhang; Rui Shi; Yiming Liu; Tsz Hung Wong; Mengge Wu; Huiling Jia; Zhan Gao; Zhibiao Zhang; Jiahui He; Mengjia Zheng; Enming Song; Lidai Wang; Chenjie Xu; Xinge Yu

doi:10.1021/acs.nanolett.2c01997

Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery

Ya Huang, Hu Li, Tianli Hu, Jian Li, Chun Ki Yiu, Jingkun Zhou, Jiyu Li, Xingcan Huang, Kuanming Yao, Xiao Qiu, Yu Zhou, Dengfeng Li, Binbin Zhang, Rui Shi, Yiming Liu, Tsz Hung Wong, Mengge Wu, Huiling Jia, Zhan Gao, Zhibiao ZhangJiahui He, Mengjia Zheng, Enming Song, Lidai Wang, Chenjie Xu^*, Xinge Yu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

82 Citations (Scopus)

Abstract

A combined treatment using medication and electrostimulation increases its effectiveness in comparison with one treatment alone. However, the organic integration of two strategies in one miniaturized system for practical usage has seldom been reported. This article reports an implantable electronic medicine based on bioresorbable microneedle devices that is activated wirelessly for electrostimulation and sustainable delivery of anti-inflammatory drugs. The electronic medicine is composed of a radio frequency wireless power transmission system and a drug-loaded microneedle structure, all fabricated with bioresorbable materials. In a rat skeletal muscle injury model, periodic electrostimulation regulates cell behaviors and tissue regeneration while the anti-inflammatory drugs prevent inflammation, which ultimately enhance the skeletal muscle regeneration. Finally, the electronic medicine is fully bioresorbable, excluding the second surgery for device removal. © 2022 American Chemical Society.

Original language	English
Pages (from-to)	5944–5953
Journal	Nano Letters
Volume	22
Issue number	14
Online published	11 Jul 2022
DOIs	https://doi.org/10.1021/acs.nanolett.2c01997
Publication status	Published - 27 Jul 2022

Funding

This work was supported by the City University of Hong Kong (Grant Nos. 9667221 and 9680322), the Research Grants Council of the Hong Kong Special Administrative Region (Grant Nos. 21210820 and 11213721), the National Natural Science Foundation of China (Grant Nos. 62122002), the Shenzhen Science and Technology Innovation Commission (Grant No. JCYJ20200109110201713), the Hong Kong Centre for Cerebro-cardiovascular Health Engineering (COCHE), the Center of Flexible Electronics Technology. C.X. acknowledges funding support from the City University of Hong Kong (9610472, 7020029), the General Research Fund (GRF) from the University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) (CityU 11202021 and 11200820), the NSFC/RGC Joint Research Scheme (N_CityU118/20), and the Germany/Hong Kong Joint Research Scheme sponsored by the RGC of Hong Kong and the Germany Academic Exchange Service of Germany (G_CityU101/21). E.S. acknowledges support from the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01), ZJ Lab, and the Shanghai Center for Brain Science and Brain-Inspired Technology.

Research Keywords

electronic medicine
implantable electronics
microneedle
drug delivery
electrostimulation
ELECTRICAL-STIMULATION
TRANSIENT
DIFFERENTIATION
CORROSION
METALS
GOLD

RGC Funding Information

RGC-funded

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Huang, Y., Li, H., Hu, T., Li, J., Yiu, C. K., Zhou, J., Li, J., Huang, X., Yao, K., Qiu, X., Zhou, Y., Li, D., Zhang, B., Shi, R., Liu, Y., Wong, T. H., Wu, M., Jia, H., Gao, Z., ... Yu, X. (2022). Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery. Nano Letters, 22(14), 5944–5953. https://doi.org/10.1021/acs.nanolett.2c01997

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abstract = "A combined treatment using medication and electrostimulation increases its effectiveness in comparison with one treatment alone. However, the organic integration of two strategies in one miniaturized system for practical usage has seldom been reported. This article reports an implantable electronic medicine based on bioresorbable microneedle devices that is activated wirelessly for electrostimulation and sustainable delivery of anti-inflammatory drugs. The electronic medicine is composed of a radio frequency wireless power transmission system and a drug-loaded microneedle structure, all fabricated with bioresorbable materials. In a rat skeletal muscle injury model, periodic electrostimulation regulates cell behaviors and tissue regeneration while the anti-inflammatory drugs prevent inflammation, which ultimately enhance the skeletal muscle regeneration. Finally, the electronic medicine is fully bioresorbable, excluding the second surgery for device removal. {\textcopyright} 2022 American Chemical Society.",

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author = "Ya Huang and Hu Li and Tianli Hu and Jian Li and Yiu, {Chun Ki} and Jingkun Zhou and Jiyu Li and Xingcan Huang and Kuanming Yao and Xiao Qiu and Yu Zhou and Dengfeng Li and Binbin Zhang and Rui Shi and Yiming Liu and Wong, {Tsz Hung} and Mengge Wu and Huiling Jia and Zhan Gao and Zhibiao Zhang and Jiahui He and Mengjia Zheng and Enming Song and Lidai Wang and Chenjie Xu and Xinge Yu",

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Huang, Y, Li, H, Hu, T , Li, J , Yiu, CK , Zhou, J , Li, J , Huang, X , Yao, K, Qiu, X, Zhou, Y, Li, D, Zhang, B, Shi, R, Liu, Y , Wong, TH, Wu, M, Jia, H , Gao, Z, Zhang, Z, He, J, Zheng, M, Song, E, Wang, L , Xu, C & Yu, X 2022, 'Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery', Nano Letters, vol. 22, no. 14, pp. 5944–5953. https://doi.org/10.1021/acs.nanolett.2c01997

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AU - Huang, Ya

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AU - Zhou, Jingkun

AU - Li, Jiyu

AU - Huang, Xingcan

AU - Yao, Kuanming

AU - Qiu, Xiao

AU - Zhou, Yu

AU - Li, Dengfeng

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AU - Wong, Tsz Hung

AU - Wu, Mengge

AU - Jia, Huiling

AU - Gao, Zhan

AU - Zhang, Zhibiao

AU - He, Jiahui

AU - Zheng, Mengjia

AU - Song, Enming

AU - Wang, Lidai

AU - Xu, Chenjie

AU - Yu, Xinge

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N2 - A combined treatment using medication and electrostimulation increases its effectiveness in comparison with one treatment alone. However, the organic integration of two strategies in one miniaturized system for practical usage has seldom been reported. This article reports an implantable electronic medicine based on bioresorbable microneedle devices that is activated wirelessly for electrostimulation and sustainable delivery of anti-inflammatory drugs. The electronic medicine is composed of a radio frequency wireless power transmission system and a drug-loaded microneedle structure, all fabricated with bioresorbable materials. In a rat skeletal muscle injury model, periodic electrostimulation regulates cell behaviors and tissue regeneration while the anti-inflammatory drugs prevent inflammation, which ultimately enhance the skeletal muscle regeneration. Finally, the electronic medicine is fully bioresorbable, excluding the second surgery for device removal. © 2022 American Chemical Society.

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ER -

Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery

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Research Keywords

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GRF: Intelligent Electronic Skin for Human Machine Interactions

GRF: Development of Framework Nucleic Acid based platform technology for intradermal and transdermal delivery of oligonucleotides therapeutics

GRF: Development of Highly Swellable Microneedle Skin Patches for Skin Interstitial Fluid Sampling and In Situ Transdermal Biosensing

Cite this

Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery

Abstract

Funding

Research Keywords

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

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Projects

GRF: Intelligent Electronic Skin for Human Machine Interactions

GRF: Development of Framework Nucleic Acid based platform technology for intradermal and transdermal delivery of oligonucleotides therapeutics

GRF: Development of Highly Swellable Microneedle Skin Patches for Skin Interstitial Fluid Sampling and In Situ Transdermal Biosensing

Cite this