Imaging treatment efficacy of repeated photodynamic therapy in glioblastoma using CEST MRI
Research output: Conference Papers › Abstract › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
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Publication status | Published - Jun 2023 |
Meeting
Title | 2023 ISMRM & ISMRT Annual Meeting & Exhibition |
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Location | Metro Toronto Convention Centre (MTCC) |
Place | Canada |
City | Toronto, ON |
Period | 3 - 8 June 2023 |
Link(s)
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(c049145f-9423-4fc5-b123-65a1a9957340).html |
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Abstract
Glioblastoma (GBM) is hard to treat and has poor prognosis. Photodynamic therapy (PDT) is a promising treatment for GBM. Here, we detect the treatment efficacies of different PDT schemes (repeated (re-) and single (s-) PDT) on a rodent model of GBM using CEST MRI to monitor the molecular changes associated with tumor physiology and necrosis. Significant decreases in APT and rNOE signals were detected in the rePDT group as well as decreased proliferative activities in histology when compared with sPDT. This indicates that both APT and rNOE can be a reliable approach to assess PDT treatment efficacy against GBM.
Research Area(s)
- CEST & MT, Tumor
Citation Format(s)
Imaging treatment efficacy of repeated photodynamic therapy in glioblastoma using CEST MRI. / Leung, Vivian W.M.; Lai, Joseph H.C.; Chen, Zilin et al.
2023. Abstract from 2023 ISMRM & ISMRT Annual Meeting & Exhibition, Toronto, ON, Canada.
2023. Abstract from 2023 ISMRM & ISMRT Annual Meeting & Exhibition, Toronto, ON, Canada.
Research output: Conference Papers › Abstract › peer-review