Imaging treatment efficacy of repeated photodynamic therapy in glioblastoma using CEST MRI

Vivian W.M. Leung; Joseph H.C. Lai; Zilin Chen; Jianpan Huang; Se Weon Park; Yang Liu; Charles Hu; Kannie W. Y. Chan

Imaging treatment efficacy of repeated photodynamic therapy in glioblastoma using CEST MRI

Vivian W.M. Leung, Joseph H.C. Lai, Zilin Chen, Jianpan Huang, Se Weon Park, Yang Liu, Charles Hu, Kannie W. Y. Chan^*

^*Corresponding author for this work

Research output: Conference Papers › Abstract › peer-review

Abstract

Glioblastoma (GBM) is hard to treat and has poor prognosis. Photodynamic therapy (PDT) is a promising treatment for GBM. Here, we detect the treatment efficacies of different PDT schemes (repeated (re-) and single (s-) PDT) on a rodent model of GBM using CEST MRI to monitor the molecular changes associated with tumor physiology and necrosis. Significant decreases in APT and rNOE signals were detected in the rePDT group as well as decreased proliferative activities in histology when compared with sPDT. This indicates that both APT and rNOE can be a reliable approach to assess PDT treatment efficacy against GBM.

Original language	English
Publication status	Published - Jun 2023
Event	2023 ISMRM & ISMRT Annual Meeting & Exhibition - Metro Toronto Convention Centre (MTCC), Toronto, ON, Canada Duration: 3 Jun 2023 → 8 Jun 2023 https://www.ismrm.org/23m/

Meeting

Meeting	2023 ISMRM & ISMRT Annual Meeting & Exhibition
Place	Canada
City	Toronto, ON
Period	3/06/23 → 8/06/23
Internet address	https://www.ismrm.org/23m/

Research Keywords

CEST & MT
Tumor

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@conference{c049145f94234fc5b12365a1a9957340,

title = "Imaging treatment efficacy of repeated photodynamic therapy in glioblastoma using CEST MRI",

abstract = "Glioblastoma (GBM) is hard to treat and has poor prognosis. Photodynamic therapy (PDT) is a promising treatment for GBM. Here, we detect the treatment efficacies of different PDT schemes (repeated (re-) and single (s-) PDT) on a rodent model of GBM using CEST MRI to monitor the molecular changes associated with tumor physiology and necrosis. Significant decreases in APT and rNOE signals were detected in the rePDT group as well as decreased proliferative activities in histology when compared with sPDT. This indicates that both APT and rNOE can be a reliable approach to assess PDT treatment efficacy against GBM.",

keywords = "CEST & MT, Tumor",

author = "Leung, {Vivian W.M.} and Lai, {Joseph H.C.} and Zilin Chen and Jianpan Huang and Park, {Se Weon} and Yang Liu and Charles Hu and Chan, {Kannie W. Y.}",

year = "2023",

month = jun,

language = "English",

note = "2023 ISMRM & ISMRT Annual Meeting & Exhibition ; Conference date: 03-06-2023 Through 08-06-2023",

url = "https://www.ismrm.org/23m/",

}

TY - CONF

T1 - Imaging treatment efficacy of repeated photodynamic therapy in glioblastoma using CEST MRI

AU - Leung, Vivian W.M.

AU - Lai, Joseph H.C.

AU - Chen, Zilin

AU - Huang, Jianpan

AU - Park, Se Weon

AU - Liu, Yang

AU - Hu, Charles

AU - Chan, Kannie W. Y.

PY - 2023/6

Y1 - 2023/6

N2 - Glioblastoma (GBM) is hard to treat and has poor prognosis. Photodynamic therapy (PDT) is a promising treatment for GBM. Here, we detect the treatment efficacies of different PDT schemes (repeated (re-) and single (s-) PDT) on a rodent model of GBM using CEST MRI to monitor the molecular changes associated with tumor physiology and necrosis. Significant decreases in APT and rNOE signals were detected in the rePDT group as well as decreased proliferative activities in histology when compared with sPDT. This indicates that both APT and rNOE can be a reliable approach to assess PDT treatment efficacy against GBM.

AB - Glioblastoma (GBM) is hard to treat and has poor prognosis. Photodynamic therapy (PDT) is a promising treatment for GBM. Here, we detect the treatment efficacies of different PDT schemes (repeated (re-) and single (s-) PDT) on a rodent model of GBM using CEST MRI to monitor the molecular changes associated with tumor physiology and necrosis. Significant decreases in APT and rNOE signals were detected in the rePDT group as well as decreased proliferative activities in histology when compared with sPDT. This indicates that both APT and rNOE can be a reliable approach to assess PDT treatment efficacy against GBM.

KW - CEST & MT

KW - Tumor

M3 - Abstract

T2 - 2023 ISMRM & ISMRT Annual Meeting & Exhibition

Y2 - 3 June 2023 through 8 June 2023

ER -

Imaging treatment efficacy of repeated photodynamic therapy in glioblastoma using CEST MRI

Abstract

Meeting

Research Keywords

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