Imaging injectable liposomal hydrogels using CEST MRI for applications in the brain

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)Abstract

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Detail(s)

Original languageEnglish
Publication statusPublished - May 2019

Conference

Title27th International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2019)
LocationPalais des congrès de Montréal
PlaceCanada
CityMontréal
Period11 - 16 May 2019

Abstract

Nanocarrier-loaded hydrogel shows good prospects in biomedical application. However, there is lack of noninvasive methods for real time monitoring to guide therapy. Here, we developed a CEST-nanosensor incorporated injectable hydrogel using two most commonly used hydrogel (alginate, and hyaluronan-methylcellulose (HAMC)) and liposomes. Both hydrogels showed storage modulus (G’) comparable to native brain tissue and good injectabilities. Moreover, we observed that our LipoCEST hydrogels generate unique CEST contrasts at 5 ppm (barbituric acid (BA), drug) and -3.4 ppm (liposomes) on 3T, facilitating the multicolor CEST imaging and imaging-guided therapy in brain applications.

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Research Unit(s) information for this publication is provided by the author(s) concerned.

Citation Format(s)

Imaging injectable liposomal hydrogels using CEST MRI for applications in the brain. / Han, Xiongqi; Huang, Jianpan; Xiao, Peng; Lai, Joseph Ho Chi; Chan, Kannie Wai Yan.

2019. Abstract from 27th International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition (ISMRM 2019), Montréal, Canada.

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)Abstract