Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and blaIMP-4-Bearing Plasmids

Qiaoling Sun; Hanyu Wang; Lingbin Shu; Ning Dong; Fan Yang; Hongwei Zhou; Sheng Chen; Rong Zhang

doi:10.3389/fmicb.2019.02805

Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and bla_IMP-4-Bearing Plasmids

Qiaoling Sun (Co-first Author), Hanyu Wang (Co-first Author), Lingbin Shu, Ning Dong, Fan Yang, Hongwei Zhou, Sheng Chen, Rong Zhang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

13 Citations (Scopus)

22 Downloads (CityUHK Scholars)

Abstract

A clinical Leclercia adecarboxylata strain harboring the mcr-4.3 and bla_IMP-4 genes was isolated from active rectal screening of carbapenem-resistant Enterobacteriaceae (CRE) in a patient. The isolate was found to harbor seven plasmids, including a 94,635 bp bla_IMP-4-bearing IncN plasmid and a 9,782 bp mcr-4.3-bearing ColE10-type plasmid. The isolate was susceptible to colistin despite carrying the mcr-4.3 gene, suggesting that this MCR-4 variant may not be functional. Carriage of antibiotic resistance genes in human gut L. adecarboxylata strain suggests that close surveillance of resistance strains in the human gut flora should be included as a routine clinical practice to prevent occurrence of infections, especially among immunocompromised patients. © Copyright © 2019 Sun, Wang, Shu, Dong, Yang, Zhou, Chen and Zhang.

Original language	English
Article number	2805
Journal	Frontiers in Microbiology
Volume	10
Online published	5 Dec 2019
DOIs	https://doi.org/10.3389/fmicb.2019.02805
Publication status	Published - Dec 2019
Externally published	Yes

Research Keywords

carbapenem resistance
colistin-susceptibility
gut flora
Leclercia adecarboxylata
mcr-4.3

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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Cite this

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title = "Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and blaIMP-4-Bearing Plasmids",

abstract = "A clinical Leclercia adecarboxylata strain harboring the mcr-4.3 and blaIMP-4 genes was isolated from active rectal screening of carbapenem-resistant Enterobacteriaceae (CRE) in a patient. The isolate was found to harbor seven plasmids, including a 94,635 bp blaIMP-4-bearing IncN plasmid and a 9,782 bp mcr-4.3-bearing ColE10-type plasmid. The isolate was susceptible to colistin despite carrying the mcr-4.3 gene, suggesting that this MCR-4 variant may not be functional. Carriage of antibiotic resistance genes in human gut L. adecarboxylata strain suggests that close surveillance of resistance strains in the human gut flora should be included as a routine clinical practice to prevent occurrence of infections, especially among immunocompromised patients. {\textcopyright} Copyright {\textcopyright} 2019 Sun, Wang, Shu, Dong, Yang, Zhou, Chen and Zhang.",

keywords = "carbapenem resistance, colistin-susceptibility, gut flora, Leclercia adecarboxylata, mcr-4.3",

author = "Qiaoling Sun and Hanyu Wang and Lingbin Shu and Ning Dong and Fan Yang and Hongwei Zhou and Sheng Chen and Rong Zhang",

year = "2019",

month = dec,

doi = "10.3389/fmicb.2019.02805",

language = "English",

volume = "10",

journal = "Frontiers in Microbiology",

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TY - JOUR

T1 - Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and blaIMP-4-Bearing Plasmids

AU - Sun, Qiaoling

AU - Wang, Hanyu

AU - Shu, Lingbin

AU - Dong, Ning

AU - Yang, Fan

AU - Zhou, Hongwei

AU - Chen, Sheng

AU - Zhang, Rong

PY - 2019/12

Y1 - 2019/12

N2 - A clinical Leclercia adecarboxylata strain harboring the mcr-4.3 and blaIMP-4 genes was isolated from active rectal screening of carbapenem-resistant Enterobacteriaceae (CRE) in a patient. The isolate was found to harbor seven plasmids, including a 94,635 bp blaIMP-4-bearing IncN plasmid and a 9,782 bp mcr-4.3-bearing ColE10-type plasmid. The isolate was susceptible to colistin despite carrying the mcr-4.3 gene, suggesting that this MCR-4 variant may not be functional. Carriage of antibiotic resistance genes in human gut L. adecarboxylata strain suggests that close surveillance of resistance strains in the human gut flora should be included as a routine clinical practice to prevent occurrence of infections, especially among immunocompromised patients. © Copyright © 2019 Sun, Wang, Shu, Dong, Yang, Zhou, Chen and Zhang.

AB - A clinical Leclercia adecarboxylata strain harboring the mcr-4.3 and blaIMP-4 genes was isolated from active rectal screening of carbapenem-resistant Enterobacteriaceae (CRE) in a patient. The isolate was found to harbor seven plasmids, including a 94,635 bp blaIMP-4-bearing IncN plasmid and a 9,782 bp mcr-4.3-bearing ColE10-type plasmid. The isolate was susceptible to colistin despite carrying the mcr-4.3 gene, suggesting that this MCR-4 variant may not be functional. Carriage of antibiotic resistance genes in human gut L. adecarboxylata strain suggests that close surveillance of resistance strains in the human gut flora should be included as a routine clinical practice to prevent occurrence of infections, especially among immunocompromised patients. © Copyright © 2019 Sun, Wang, Shu, Dong, Yang, Zhou, Chen and Zhang.

KW - carbapenem resistance

KW - colistin-susceptibility

KW - gut flora

KW - Leclercia adecarboxylata

KW - mcr-4.3

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U2 - 10.3389/fmicb.2019.02805

DO - 10.3389/fmicb.2019.02805

M3 - RGC 21 - Publication in refereed journal

C2 - 31866974

SN - 1664-302X

VL - 10

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

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ER -