In vivo tracking of adipose tissue grafts with cadmium-telluride quantum dots

Claus J. Deglmann; Katarzyna Błażków-Schmalzbauer; Sarah Moorkamp; Jens Wallmichrath; Riccardo E. Giunta; Andrey L. Rogach; Ernst Wagner; Ruediger G. Baumeister; Manfred Ogris

doi:10.5999/aps.2017.01487

In vivo tracking of adipose tissue grafts with cadmium-telluride quantum dots

Claus J. Deglmann^*, Katarzyna Błażków-Schmalzbauer, Sarah Moorkamp, Jens Wallmichrath, Riccardo E. Giunta, Andrey L. Rogach, Ernst Wagner, Ruediger G. Baumeister, Manfred Ogris

^*Corresponding author for this work

Centre for Functional Photonics

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Abstract

Background Fat grafting, or lipofilling, represent frequent clinically used entities. The fate of these transplants is still not predictable, whereas only few animal models are available for further research. Quantum dots (QDs) are semiconductor nanocrystals which can be conveniently tracked in vivo due to photoluminescence.
Methods Fat grafts in cluster form were labeled with cadmium-telluride (CdTe)-QD 770 and transplanted subcutaneously in a murine in vivo model. Photoluminescence levels were serially followed in vivo.
Results Tracing of fat grafts was possible for 50 days with CdTe-QD 770. The remaining photoluminescence was 4.9%±2.5% for the QDs marked fat grafts after 30 days and 4.2%± 1.7% after 50 days. There was no significant correlation in the relative course of the tracking signal, when vital fat transplants were compared to non-vital graft controls.
Conclusions For the first-time fat grafts were tracked in vivo with CdTe-QDs. CdTe-QDs could offer a new option for in vivo tracking of fat grafts for at least 50 days, but do not document vitality of the grafts.

Original language	English
Pages (from-to)	111-117
Journal	Archives of Plastic Surgery
Volume	45
Issue number	2
Online published	5 Mar 2018
DOIs	https://doi.org/10.5999/aps.2017.01487
Publication status	Published - Mar 2018

Research Keywords

Adipocytes
Adipose tissue
Quantum dots
Transplantation

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This full text is made available under CC-BY-NC 4.0. https://creativecommons.org/licenses/by-nc/4.0/

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title = "In vivo tracking of adipose tissue grafts with cadmium-telluride quantum dots",

abstract = "Background Fat grafting, or lipofilling, represent frequent clinically used entities. The fate of these transplants is still not predictable, whereas only few animal models are available for further research. Quantum dots (QDs) are semiconductor nanocrystals which can be conveniently tracked in vivo due to photoluminescence. Methods Fat grafts in cluster form were labeled with cadmium-telluride (CdTe)-QD 770 and transplanted subcutaneously in a murine in vivo model. Photoluminescence levels were serially followed in vivo. Results Tracing of fat grafts was possible for 50 days with CdTe-QD 770. The remaining photoluminescence was 4.9%±2.5% for the QDs marked fat grafts after 30 days and 4.2%± 1.7% after 50 days. There was no significant correlation in the relative course of the tracking signal, when vital fat transplants were compared to non-vital graft controls. Conclusions For the first-time fat grafts were tracked in vivo with CdTe-QDs. CdTe-QDs could offer a new option for in vivo tracking of fat grafts for at least 50 days, but do not document vitality of the grafts.",

keywords = "Adipocytes, Adipose tissue, Quantum dots, Transplantation",

author = "Deglmann, {Claus J.} and Katarzyna B{\l}a{\.z}k{\'o}w-Schmalzbauer and Sarah Moorkamp and Jens Wallmichrath and Giunta, {Riccardo E.} and Rogach, {Andrey L.} and Ernst Wagner and Baumeister, {Ruediger G.} and Manfred Ogris",

year = "2018",

month = mar,

doi = "10.5999/aps.2017.01487",

language = "English",

volume = "45",

pages = "111--117",

journal = "Archives of Plastic Surgery",

issn = "2234-6163",

publisher = "Georg Thieme Verlag",

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TY - JOUR

T1 - In vivo tracking of adipose tissue grafts with cadmium-telluride quantum dots

AU - Deglmann, Claus J.

AU - Błażków-Schmalzbauer, Katarzyna

AU - Moorkamp, Sarah

AU - Wallmichrath, Jens

AU - Giunta, Riccardo E.

AU - Rogach, Andrey L.

AU - Wagner, Ernst

AU - Baumeister, Ruediger G.

AU - Ogris, Manfred

PY - 2018/3

Y1 - 2018/3

N2 - Background Fat grafting, or lipofilling, represent frequent clinically used entities. The fate of these transplants is still not predictable, whereas only few animal models are available for further research. Quantum dots (QDs) are semiconductor nanocrystals which can be conveniently tracked in vivo due to photoluminescence. Methods Fat grafts in cluster form were labeled with cadmium-telluride (CdTe)-QD 770 and transplanted subcutaneously in a murine in vivo model. Photoluminescence levels were serially followed in vivo. Results Tracing of fat grafts was possible for 50 days with CdTe-QD 770. The remaining photoluminescence was 4.9%±2.5% for the QDs marked fat grafts after 30 days and 4.2%± 1.7% after 50 days. There was no significant correlation in the relative course of the tracking signal, when vital fat transplants were compared to non-vital graft controls. Conclusions For the first-time fat grafts were tracked in vivo with CdTe-QDs. CdTe-QDs could offer a new option for in vivo tracking of fat grafts for at least 50 days, but do not document vitality of the grafts.

AB - Background Fat grafting, or lipofilling, represent frequent clinically used entities. The fate of these transplants is still not predictable, whereas only few animal models are available for further research. Quantum dots (QDs) are semiconductor nanocrystals which can be conveniently tracked in vivo due to photoluminescence. Methods Fat grafts in cluster form were labeled with cadmium-telluride (CdTe)-QD 770 and transplanted subcutaneously in a murine in vivo model. Photoluminescence levels were serially followed in vivo. Results Tracing of fat grafts was possible for 50 days with CdTe-QD 770. The remaining photoluminescence was 4.9%±2.5% for the QDs marked fat grafts after 30 days and 4.2%± 1.7% after 50 days. There was no significant correlation in the relative course of the tracking signal, when vital fat transplants were compared to non-vital graft controls. Conclusions For the first-time fat grafts were tracked in vivo with CdTe-QDs. CdTe-QDs could offer a new option for in vivo tracking of fat grafts for at least 50 days, but do not document vitality of the grafts.

KW - Adipocytes

KW - Adipose tissue

KW - Quantum dots

KW - Transplantation

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In vivo tracking of adipose tissue grafts with cadmium-telluride quantum dots

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