Abstract
Microneedle technology allows micron-sized conduits to be formed within the outermost skin layers for both localized and systemic delivery of therapeutics including nanoparticles. Histological methods are often employed for characterization, and unfortunately do not allow for the in vivo visualization of the delivery process. This study presents the utilization of optical resolution-photoacoustic microscopy to characterize the transdermal delivery of nanoparticles using microneedles. Specifically, we observe the in vivo transdermal delivery of gold nanoparticles using microneedles in mice ear and study the penetration, diffusion, and spatial distribution of the nanoparticles in the tissue. The promising results reveal that photoacoustic microscopy can be used as a potential imaging modality for the in vivo characterization of microneedles based drug delivery.
| Original language | English |
|---|---|
| Pages (from-to) | 5483-5492 |
| Journal | Biomedical Optics Express |
| Volume | 8 |
| Issue number | 12 |
| Online published | 9 Nov 2017 |
| DOIs | |
| Publication status | Published - 1 Dec 2017 |
| Externally published | Yes |
Research Keywords
- Photoacoustic imaging
- Photoacoustics
- Microscopy
- Photodynamic therapy
- Nanomaterials
Publisher's Copyright Statement
- © 2017 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
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