Abstract
Alpha-Gal Syndrome (AGS) is a delayed allergic reaction triggered by IgE antibodies targeting galactose-α-1,3-galactose (α-gal), prevalent in red meat. Its global significance has increased, with over 450,000 estimated cases in the United States alone. AGS is linked to tick bites, causing sensitization and elevated α-gal specific IgE levels. However, the precise mechanisms and tick intrinsic factors contributing to AGS development post-tick bites remain unclear. This study aims to characterize the alpha-gal conjugated lipid antigens in Amblyomma americanum (Am. americanum) salivary glands and saliva. Nanospray ionization mass spectrometry (NSI-MS) analysis revealed the identification of α-gal bound lipid antigens in Am. americanum saliva. Additionally, the activation of basophils by extracted alpha-gal bound lipids and proteins provides evidence of their antigenic capabilities. © 2024 The Author(s)
| Original language | English |
|---|---|
| Article number | 102384 |
| Journal | Ticks and Tick-borne Diseases |
| Volume | 15 |
| Issue number | 6 |
| Online published | 24 Jul 2024 |
| DOIs | |
| Publication status | Published - Nov 2024 |
Research Keywords
- Alpha-gal bound lipid
- Alpha-Gal Syndrome
- Amblyomma americanum
- Basophil activation test
- Food allergy
- IgE
- Tick bites
Publisher's Copyright Statement
- This full text is made available under CC-BY-NC-ND 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/
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