Identification of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam from ST11 Carbapenem-Resistant Klebsiella pneumoniae Strains
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Journal / Publication | Microbiology Spectrum |
Volume | 10 |
Issue number | 2 |
Publication status | Published - Mar 2022 |
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DOI | DOI |
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Attachment(s) | Documents
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85129343585&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(eac277e4-dca0-40e6-92b1-f8eda20385b0).html |
Abstract
A novel Klebsiella pneumoniae carbapenemase (KPC) variant, KPC-93, was identified in two Klebsiella pneumoniae clinical isolates from a patient from China treated with ceftazidime-avibactam. KPC-93 possessed a five-amino-acids insertion (Pro-Asn-Asn-Arg-Ala) between Ambler positions 267 and 268 in KPC-2. Cloning and expression of the blaKPC-93 gene in Escherichia coli, followed by determination of minimum inhibitory concentration (MIC) values and kinetic parameters, showed that KPC-93 exhibited increased resistance to ceftazidime-avibactam, but a drastic decrease in carbapenemase activity. Our data highlight that a KPC variant conferring resistance to ceftazidime-avibactam could be easily induced by ceftazidime-avibactam treatment and that actions are required to control dissemination of these determinants.
Research Area(s)
- KPC, ceftazidime-avibactam, Klebsiella pneumoniae, SUSCEPTIBILITY, TOOL
Citation Format(s)
Identification of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam from ST11 Carbapenem-Resistant Klebsiella pneumoniae Strains. / Wu, Yuchen; Yang, Xuemei; Liu, Congcong et al.
In: Microbiology Spectrum, Vol. 10, No. 2, 03.2022.
In: Microbiology Spectrum, Vol. 10, No. 2, 03.2022.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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