Hypocholesterolemic activity of hawthorn fruit is mediated by regulation of cholesterol-7α-hydroxylase and acyl CoA : Cholesterol acyltransferase

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Zesheng Zhang
  • Walter K.K Ho
  • Yu Huang
  • Zhen-Yu Chen

Detail(s)

Original languageEnglish
Pages (from-to)885-891
Journal / PublicationFood Research International
Volume35
Issue number9
Publication statusPublished - 2002
Externally publishedYes

Abstract

The present study was to investigate the mechanisms by which hawthorn fruit lowers serum cholesterol in hamsters. The control group was fed a semisynthetic diet containing 0.1% cholesterol while the tested group was maintained on the same diet but supplemented with 0.5% hawthorn fruit aqueous ethanolic extract for 4 weeks. Serum total cholesterol (TC) and triacylglycerols (TG) were decreased by 10 and 13%, respectively, in hawthorn fruit group as compared with the control (P<0.05). Supplementation of hawthorn fruit aqueous ethanolic extract led to greater excretion of both neutral and acidic sterols. Further enzymatic assays suggest the mechanisms by which hawthorn fruit decreases serum cholesterol involve a greater excretion of bile acids mediated by up-regulation of hepatic cholesterol 7α-hydroxylase (CH) activity, and an inhibition of cholesterol absorption mediated by down-regulation of intestinal acyl CoA:cholesterol acyltransferase (ACAT) activity. © 2002 Elsevier Science Ltd. All rights reserved.

Research Area(s)

  • Cholesterol, Crataegus pinnatifida, Hamster, Hawthorn fruit, Triglyceride

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Citation Format(s)

Hypocholesterolemic activity of hawthorn fruit is mediated by regulation of cholesterol-7α-hydroxylase and acyl CoA: Cholesterol acyltransferase. / Zhang, Zesheng; Ho, Walter K.K; Huang, Yu et al.
In: Food Research International, Vol. 35, No. 9, 2002, p. 885-891.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review