Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles

Hao-Yu Tseng; Chen-Yi Lee; Ying-Hsia Shih; Xi-Zhang Lin; Gwo-Bin Lee

doi:10.1109/NEMS.2007.352253

Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles

Hao-Yu Tseng
, Chen-Yi Lee
, Ying-Hsia Shih
, Xi-Zhang Lin
, Gwo-Bin Lee^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

4 Citations (Scopus)

Abstract

This paper presents an investigation of hyperthermia cancer therapy utilizing high-frequency magnetic field to induce a temperature increase on tumor cells by using a commercially-available radiography solution containing superparamagnetic nanoparticles. The biocompatible and biodegradable materials allow us to explore hyperthermia cancer therapy in vivo or in vitro. Experimental data showed that a temperature as high as 72.4°C can be successfully generated for in vitro experiments. In-vitro testing showed that survival rate of the tumor cells can be greatly reduced. In-vivo experiments showed that the hyperthermia therapy can significantly repress the growth of liver tumors by utilizing concentrated commercial nanoparticles and temperature-sensitive hydrogel. Hydrogel used in drug delivery system was liquid at low temperature (<20°C) and became gel above 30°C. The gel can be used to secure the nanoparticles in the target tumor tissue. Furthermore, a temperature control system was designed to keep the nanoparticles at a constant temperature such that a reliable cancer therapy can be feasible. © 2007 IEEE.

Original language	English
Title of host publication	Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Pages	163-166
DOIs	https://doi.org/10.1109/NEMS.2007.352253
Publication status	Published - 2007
Externally published	Yes
Event	2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, Thailand Duration: 16 Jan 2007 → 19 Jan 2007

Publication series

Name	Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Conference

Conference	2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Place	Thailand
City	Bangkok
Period	16/01/07 → 19/01/07

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Alternating magnetic field
Cancer therapy
Hyperthermia
Magnetic nanoparticle

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10.1109/NEMS.2007.352253

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Cite this

Tseng, H.-Y., Lee, C.-Y., Shih, Y.-H., Lin, X.-Z., & Lee, G.-B. (2007). Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 (pp. 163-166). Article 4160556 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). https://doi.org/10.1109/NEMS.2007.352253

Tseng, Hao-Yu ; Lee, Chen-Yi ; Shih, Ying-Hsia et al. / Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. pp. 163-166 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

@inproceedings{f094c298804844c9aaeebe2731f7eb69,

title = "Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles",

abstract = "This paper presents an investigation of hyperthermia cancer therapy utilizing high-frequency magnetic field to induce a temperature increase on tumor cells by using a commercially-available radiography solution containing superparamagnetic nanoparticles. The biocompatible and biodegradable materials allow us to explore hyperthermia cancer therapy in vivo or in vitro. Experimental data showed that a temperature as high as 72.4°C can be successfully generated for in vitro experiments. In-vitro testing showed that survival rate of the tumor cells can be greatly reduced. In-vivo experiments showed that the hyperthermia therapy can significantly repress the growth of liver tumors by utilizing concentrated commercial nanoparticles and temperature-sensitive hydrogel. Hydrogel used in drug delivery system was liquid at low temperature (<20°C) and became gel above 30°C. The gel can be used to secure the nanoparticles in the target tumor tissue. Furthermore, a temperature control system was designed to keep the nanoparticles at a constant temperature such that a reliable cancer therapy can be feasible. {\textcopyright} 2007 IEEE.",

keywords = "Alternating magnetic field, Cancer therapy, Hyperthermia, Magnetic nanoparticle",

author = "Hao-Yu Tseng and Chen-Yi Lee and Ying-Hsia Shih and Xi-Zhang Lin and Gwo-Bin Lee",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].; 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 ; Conference date: 16-01-2007 Through 19-01-2007",

year = "2007",

doi = "10.1109/NEMS.2007.352253",

language = "English",

isbn = "1424406102",

series = "Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007",

pages = "163--166",

booktitle = "Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007",

}

Tseng, H-Y, Lee, C-Y, Shih, Y-H, Lin, X-Z & Lee, G-B 2007, Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. in Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007., 4160556, Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, pp. 163-166, 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, Bangkok, Thailand, 16/01/07. https://doi.org/10.1109/NEMS.2007.352253

Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. / Tseng, Hao-Yu; Lee, Chen-Yi; Shih, Ying-Hsia et al.
Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 163-166 4160556 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles

AU - Tseng, Hao-Yu

AU - Lee, Chen-Yi

AU - Shih, Ying-Hsia

AU - Lin, Xi-Zhang

AU - Lee, Gwo-Bin

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2007

Y1 - 2007

N2 - This paper presents an investigation of hyperthermia cancer therapy utilizing high-frequency magnetic field to induce a temperature increase on tumor cells by using a commercially-available radiography solution containing superparamagnetic nanoparticles. The biocompatible and biodegradable materials allow us to explore hyperthermia cancer therapy in vivo or in vitro. Experimental data showed that a temperature as high as 72.4°C can be successfully generated for in vitro experiments. In-vitro testing showed that survival rate of the tumor cells can be greatly reduced. In-vivo experiments showed that the hyperthermia therapy can significantly repress the growth of liver tumors by utilizing concentrated commercial nanoparticles and temperature-sensitive hydrogel. Hydrogel used in drug delivery system was liquid at low temperature (<20°C) and became gel above 30°C. The gel can be used to secure the nanoparticles in the target tumor tissue. Furthermore, a temperature control system was designed to keep the nanoparticles at a constant temperature such that a reliable cancer therapy can be feasible. © 2007 IEEE.

AB - This paper presents an investigation of hyperthermia cancer therapy utilizing high-frequency magnetic field to induce a temperature increase on tumor cells by using a commercially-available radiography solution containing superparamagnetic nanoparticles. The biocompatible and biodegradable materials allow us to explore hyperthermia cancer therapy in vivo or in vitro. Experimental data showed that a temperature as high as 72.4°C can be successfully generated for in vitro experiments. In-vitro testing showed that survival rate of the tumor cells can be greatly reduced. In-vivo experiments showed that the hyperthermia therapy can significantly repress the growth of liver tumors by utilizing concentrated commercial nanoparticles and temperature-sensitive hydrogel. Hydrogel used in drug delivery system was liquid at low temperature (<20°C) and became gel above 30°C. The gel can be used to secure the nanoparticles in the target tumor tissue. Furthermore, a temperature control system was designed to keep the nanoparticles at a constant temperature such that a reliable cancer therapy can be feasible. © 2007 IEEE.

KW - Alternating magnetic field

KW - Cancer therapy

KW - Hyperthermia

KW - Magnetic nanoparticle

UR - https://www.scopus.com/pages/publications/34548120243

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-34548120243&origin=recordpage

U2 - 10.1109/NEMS.2007.352253

DO - 10.1109/NEMS.2007.352253

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 1424406102

SN - 9781424406104

T3 - Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

SP - 163

EP - 166

BT - Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

T2 - 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Y2 - 16 January 2007 through 19 January 2007

ER -

Tseng HY, Lee CY, Shih YH, Lin XZ, Lee GB. Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 163-166. 4160556. (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). doi: 10.1109/NEMS.2007.352253

Hyperthermia cancer therapy utilizing superparamagnetic nanoparticles

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

Research Keywords

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