Hydrolytic degradation of electron beam irradiated high molecular weight and non-irradiated moderate molecular weight PLLA

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)287-296
Journal / PublicationActa Biomaterialia
Volume2
Issue number3
Online published6 Dec 2005
Publication statusPublished - May 2006
Externally publishedYes

Abstract

The purpose of this study is to examine the hydrolytic degradation of electron beam irradiated ring-opening polymerized (ROP) poly(l-lactide) (PLLA-ir) and non-irradiated melt polycondensation polymerized poly(l-lactic acid) (PLLA-pc). It was observed that irradiation increases the hydrolytic degradation rate constant for ROP PLLA. This was due to a more hydrophilic PLLA-ir, as a result of irradiation. The degradation rate constants (k) of PLLA-ir samples were also found to be similar, regardless of the radiation dose, and an empirically formulated equation relating hydrolytic degradation time span to radiation dose was derived. The k value for PLLA-pc was observed to be lower than that for PLLA-ir, though the latter had a higher molecular weight. This was due to the difference in degradation mechanism, in which PLLA-ir undergoes end group scission, through a backbiting mechanism, during hydrolysis and thus a faster hydrolysis rate. Electron beam irradiation, though accelerates the degradation of PLLA, has been shown to be useful in accurately controlling the hydrolytic time span of PLLA. This method of controlling the hydrolytic degradation time was by far an easier task than through melt polycondensation polymerization. This would allow PLLA to be used for drug delivery purposes or as a temporary implant that requires a moderate time span (3-6 months). © 2005 Acta Materialia Inc.

Research Area(s)

  • Chain end scission, Electron beam radiation, Hydrolytic degradation, Melt polycondensation polymerization, PLLA

Citation Format(s)

Hydrolytic degradation of electron beam irradiated high molecular weight and non-irradiated moderate molecular weight PLLA. / Loo, Say Chye Joachim; Tan, Hui Tong; Ooi, Chui Ping et al.
In: Acta Biomaterialia, Vol. 2, No. 3, 05.2006, p. 287-296.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review