Hydrolytic degradation characteristics of irradiated multi-layered PLGA films

Say Chye Joachim Loo; Wei Li Jason Tan; Shu Min Khoa; Ngeow Khing Chia; Subbu Venkatraman; Freddy Boey

doi:10.1016/j.ijpharm.2008.04.017

Hydrolytic degradation characteristics of irradiated multi-layered PLGA films

Say Chye Joachim Loo^*, Wei Li Jason Tan, Shu Min Khoa, Ngeow Khing Chia, Subbu Venkatraman, Freddy Boey

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

30 Citations (Scopus)

Abstract

Poly(lactide-co-glycolide) (PLGA) has been extensively investigated for controlled drug release. Because they undergo bulk degradation, they do not allow for a good controlled-release of drugs. The objective of this study is therefore to understand if a multi-layer-cum-irradiation technique would elicit surface erosion from PLGA polymers. A linear loss of mass and film thinning from PLGA films were observed. Also, the erosion of the top layer, of this multi-layered structure, accelerates degradation of the underlying layers. It is this effect that results in the observed pseudo-surface erosion for irradiated multi-layered PLGA. © 2008 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	228-230
Journal	International Journal of Pharmaceutics
Volume	360
Issue number	1-2
Online published	16 Apr 2008
DOIs	https://doi.org/10.1016/j.ijpharm.2008.04.017
Publication status	Published - 6 Aug 2008
Externally published	Yes

Research Keywords

Electron beam irradiation
PLGA
Surface erosion

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10.1016/j.ijpharm.2008.04.017

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title = "Hydrolytic degradation characteristics of irradiated multi-layered PLGA films",

abstract = "Poly(lactide-co-glycolide) (PLGA) has been extensively investigated for controlled drug release. Because they undergo bulk degradation, they do not allow for a good controlled-release of drugs. The objective of this study is therefore to understand if a multi-layer-cum-irradiation technique would elicit surface erosion from PLGA polymers. A linear loss of mass and film thinning from PLGA films were observed. Also, the erosion of the top layer, of this multi-layered structure, accelerates degradation of the underlying layers. It is this effect that results in the observed pseudo-surface erosion for irradiated multi-layered PLGA. {\textcopyright} 2008 Elsevier B.V. All rights reserved.",

keywords = "Electron beam irradiation, PLGA, Surface erosion",

author = "{Joachim Loo}, {Say Chye} and {Jason Tan}, {Wei Li} and Khoa, {Shu Min} and Chia, {Ngeow Khing} and Subbu Venkatraman and Freddy Boey",

year = "2008",

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doi = "10.1016/j.ijpharm.2008.04.017",

language = "English",

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journal = "International Journal of Pharmaceutics",

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TY - JOUR

T1 - Hydrolytic degradation characteristics of irradiated multi-layered PLGA films

AU - Joachim Loo, Say Chye

AU - Jason Tan, Wei Li

AU - Khoa, Shu Min

AU - Chia, Ngeow Khing

AU - Venkatraman, Subbu

AU - Boey, Freddy

PY - 2008/8/6

Y1 - 2008/8/6

N2 - Poly(lactide-co-glycolide) (PLGA) has been extensively investigated for controlled drug release. Because they undergo bulk degradation, they do not allow for a good controlled-release of drugs. The objective of this study is therefore to understand if a multi-layer-cum-irradiation technique would elicit surface erosion from PLGA polymers. A linear loss of mass and film thinning from PLGA films were observed. Also, the erosion of the top layer, of this multi-layered structure, accelerates degradation of the underlying layers. It is this effect that results in the observed pseudo-surface erosion for irradiated multi-layered PLGA. © 2008 Elsevier B.V. All rights reserved.

AB - Poly(lactide-co-glycolide) (PLGA) has been extensively investigated for controlled drug release. Because they undergo bulk degradation, they do not allow for a good controlled-release of drugs. The objective of this study is therefore to understand if a multi-layer-cum-irradiation technique would elicit surface erosion from PLGA polymers. A linear loss of mass and film thinning from PLGA films were observed. Also, the erosion of the top layer, of this multi-layered structure, accelerates degradation of the underlying layers. It is this effect that results in the observed pseudo-surface erosion for irradiated multi-layered PLGA. © 2008 Elsevier B.V. All rights reserved.

KW - Electron beam irradiation

KW - PLGA

KW - Surface erosion

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-47049103732&origin=recordpage

U2 - 10.1016/j.ijpharm.2008.04.017

DO - 10.1016/j.ijpharm.2008.04.017

M3 - RGC 21 - Publication in refereed journal

C2 - 18514448

SN - 0378-5173

VL - 360

SP - 228

EP - 230

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Hydrolytic degradation characteristics of irradiated multi-layered PLGA films

Abstract

Research Keywords

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