Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex

Xuefeng Tan; Guozhen Wang; Ziyue Zhu; Conghui Ren; Jinping Zhou; Hui Lv; Xiaoyong Zhang; Lung Wa Chung; Lina Zhang; Xumu Zhang

doi:10.1021/acs.orglett.6b00060

Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex

Xuefeng Tan, Guozhen Wang, Ziyue Zhu, Conghui Ren, Jinping Zhou, Hui Lv, Xiaoyong Zhang, Lung Wa Chung^*, Lina Zhang, Xumu Zhang

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

44 Citations (Scopus)

Abstract

A readily available ruthenium(II) catalyst was developed for the catalytic hydrogenation of aldehydes with a TON (turnover number) up to 340000. It can be performed without base and solvent, showing highly industrial potential. High chemoselectivity can be achieved in the presence of alkenyl and ketone groups. Further application of this protocol in glucose reduction showed good efficiency. Theoretical studies revealed that the rate-determining step is the hydrogenation step, not the carboxylate-assisted H₂ activation step. © 2016 American Chemical Society.

Original language	English
Pages (from-to)	1518-1521
Journal	Organic Letters
Volume	18
Issue number	7
DOIs	https://doi.org/10.1021/acs.orglett.6b00060
Publication status	Published - 15 Apr 2016
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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title = "Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex",

abstract = "A readily available ruthenium(II) catalyst was developed for the catalytic hydrogenation of aldehydes with a TON (turnover number) up to 340000. It can be performed without base and solvent, showing highly industrial potential. High chemoselectivity can be achieved in the presence of alkenyl and ketone groups. Further application of this protocol in glucose reduction showed good efficiency. Theoretical studies revealed that the rate-determining step is the hydrogenation step, not the carboxylate-assisted H2 activation step. {\textcopyright} 2016 American Chemical Society.",

author = "Xuefeng Tan and Guozhen Wang and Ziyue Zhu and Conghui Ren and Jinping Zhou and Hui Lv and Xiaoyong Zhang and Chung, {Lung Wa} and Lina Zhang and Xumu Zhang",

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T1 - Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex

AU - Tan, Xuefeng

AU - Wang, Guozhen

AU - Zhu, Ziyue

AU - Ren, Conghui

AU - Zhou, Jinping

AU - Lv, Hui

AU - Zhang, Xiaoyong

AU - Chung, Lung Wa

AU - Zhang, Lina

AU - Zhang, Xumu

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2016/4/15

Y1 - 2016/4/15

N2 - A readily available ruthenium(II) catalyst was developed for the catalytic hydrogenation of aldehydes with a TON (turnover number) up to 340000. It can be performed without base and solvent, showing highly industrial potential. High chemoselectivity can be achieved in the presence of alkenyl and ketone groups. Further application of this protocol in glucose reduction showed good efficiency. Theoretical studies revealed that the rate-determining step is the hydrogenation step, not the carboxylate-assisted H2 activation step. © 2016 American Chemical Society.

AB - A readily available ruthenium(II) catalyst was developed for the catalytic hydrogenation of aldehydes with a TON (turnover number) up to 340000. It can be performed without base and solvent, showing highly industrial potential. High chemoselectivity can be achieved in the presence of alkenyl and ketone groups. Further application of this protocol in glucose reduction showed good efficiency. Theoretical studies revealed that the rate-determining step is the hydrogenation step, not the carboxylate-assisted H2 activation step. © 2016 American Chemical Society.

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DO - 10.1021/acs.orglett.6b00060

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SN - 1523-7060

VL - 18

SP - 1518

EP - 1521

JO - Organic Letters

JF - Organic Letters

IS - 7

ER -

Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex

Abstract

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