Hybrid MoSe2-indocyanine green nanosheets as a highly efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jingqin Chen
  • Xueshen Li
  • Xiaoyang Liu
  • Huixiang Yan
  • Zhihua Xie
  • Zonghai Sheng
  • Xiaojing Gong
  • Xin Liu
  • Peng Zhang
  • Hairong Zheng
  • Liang Song
  • Chengbo Liu

Detail(s)

Original languageEnglish
Pages (from-to)1503-1516
Journal / PublicationBiomaterials Science
Volume6
Issue number6
Online published16 Mar 2018
Publication statusPublished - 1 Jun 2018

Abstract

Phototheranostic technology based on photoacoustic imaging (PAI) and photothermal therapy (PTT) is emerging as a powerful tool for tumor theranostic applications. For effective tumor eradication, a novel PAI/PTT theranostic nanoagent with an excellent optical absorption and photothermal capability is highly desired. Herein, we present a new PAI/PTT nanohybrid named sMoSe2-ICG NSs by covalently conjugating aminated indocyanine green (ICG) onto a single layer of molybdenum selenide nanosheets (sMoSe2 NSs). We first validate the sMoSe2-ICG NS agent for the PAI and PTT effect in vitro and then use it for highly-sensitive PAI guided highly efficient tumor PTT in vivo. The sMoSe2-ICG NS hybrid possesses several advantages for PAI/PTT applications: (1) the sMoSe2-ICG NSs have strong absorbance in the broad near-infrared (NIR) region, enabling a highly efficient PAI/PTT theranostic effect and the selection of the most widely used excitation wavelength of 808 nm for PTT; (2) the photothermal ability of ICG in sMoSe2-ICG NSs is augmented due to ICG aggregation induced fluorescence quenching and the re-absorbance of ICG fluorescence by sMoSe2 NSs, which further enhances the PAI/PTT theranostic effect. (3) The characteristic absorption peak of sMoSe2-ICG NSs is red-shifted compared to free ICG, resulting in a higher PAI signal-to-noise ratio (SNR) in vivo. Thus, combined with the good stability, high biocompatibility and minimal toxicity properties, the obtained sMoSe2-ICG NSs hybrid has bright prospects for use in future PAI/PTT clinical applications.

Citation Format(s)

Hybrid MoSe2-indocyanine green nanosheets as a highly efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy. / Chen, Jingqin; Li, Xueshen; Liu, Xiaoyang; Yan, Huixiang; Xie, Zhihua; Sheng, Zonghai; Gong, Xiaojing; Wang, Lidai; Liu, Xin; Zhang, Peng; Zheng, Hairong; Song, Liang; Liu, Chengbo.

In: Biomaterials Science, Vol. 6, No. 6, 01.06.2018, p. 1503-1516.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review