Hybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery

Johannes Gurke; Tobias E. Naegele; Sam Hilton; Roberto Pezone; Vincenzo F. Curto; Damiano G. Barone; Emil J. W. List-Kratochvil; Alejandro Carnicer-Lombarte; George G. Malliaras

doi:10.1039/d1mh01855h

Hybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery

Johannes Gurke (Co-first Author)
, Tobias E. Naegele (Co-first Author)
, Sam Hilton
, Roberto Pezone
, Vincenzo F. Curto
, Damiano G. Barone
, Emil J. W. List-Kratochvil
, Alejandro Carnicer-Lombarte^*
, George G. Malliaras^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

19 Citations (Scopus)

Abstract

New fabrication approaches for mechanically flexible implants hold the key to advancing the applications of neuroengineering in fundamental neuroscience and clinic. By combining the high precision of thin film microfabrication with the versatility of additive manufacturing, we demonstrate a straight-forward approach for the prototyping of intracranial implants with electrode arrays and microfluidic channels. We show that the implant can modulate neuronal activity in the hippocampus through localized drug delivery, while simultaneously recording brain activity by its electrodes. Moreover, good implant stability and minimal tissue response are seen one-week post-implantation. Our work shows the potential of hybrid fabrication combining different manufacturing techniques in neurotechnology and paves the way for a new approach to the development of multimodal implants. © 2022 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	1727-1734
Journal	Materials Horizons
Volume	9
Issue number	6
Online published	21 Apr 2022
DOIs	https://doi.org/10.1039/d1mh01855h
Publication status	Published - 1 Jun 2022
Externally published	Yes

Funding

J. G. acknowledges the support from the German Research Foundation (Deutsche Forschungsgemeinschaft DFG via Research Fellowships Gz. GU 2073/1-1). A. C. L. acknowledges Wellcome Trust for a Junior Interdisciplinary Fellowship. T. E. N. acknowledges funding from EPSRC Cambridge NanoDTC (EP/L015978/1). D. G. B. acknowledges the support by Health Education England and the National Institute for Health Research HEE/NIHR ICA Program Clinical Lectureship (CL-2019-14-004). This work was supported by the European Union's Horizon 2020 Research and Innovation Programme under grant agreement No. 732032 (BrainCom) and by the EPSRC IRC in Targeted Delivery for Hard-to-Treat Cancers (EP/S009000/1). Part of the work was carried out in the Joint Lab GEN_FAB with the support of the Helmholtz Innovation Lab HySPRINT. Hereby we grateful acknowledge the fruitful discussions with the members of the Bioelectronics Laboratorya and Hybrid Devices Groupb, especially Sanggil Han, Santiago Velasco Bosom and Felix Hermerschmidt as well as Stephan Wei\u00DF (Asiga). We thanks Christophe Bernard (INSERM) for his critical reading of the manuscript.

Publisher's Copyright Statement

This full text is made available under CC-BY 3.0. https://creativecommons.org/licenses/by/3.0/

Access Output

10.1039/d1mh01855h

408118985.pdfFinal Published version, 4.67 MBLicence: CC BY

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{c5222aa574314984a2798079766154e2,

title = "Hybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery",

abstract = "New fabrication approaches for mechanically flexible implants hold the key to advancing the applications of neuroengineering in fundamental neuroscience and clinic. By combining the high precision of thin film microfabrication with the versatility of additive manufacturing, we demonstrate a straight-forward approach for the prototyping of intracranial implants with electrode arrays and microfluidic channels. We show that the implant can modulate neuronal activity in the hippocampus through localized drug delivery, while simultaneously recording brain activity by its electrodes. Moreover, good implant stability and minimal tissue response are seen one-week post-implantation. Our work shows the potential of hybrid fabrication combining different manufacturing techniques in neurotechnology and paves the way for a new approach to the development of multimodal implants. {\textcopyright} 2022 The Royal Society of Chemistry.",

author = "Johannes Gurke and Naegele, \{Tobias E.\} and Sam Hilton and Roberto Pezone and Curto, \{Vincenzo F.\} and Barone, \{Damiano G.\} and List-Kratochvil, \{Emil J. W.\} and Alejandro Carnicer-Lombarte and Malliaras, \{George G.\}",

year = "2022",

month = jun,

day = "1",

doi = "10.1039/d1mh01855h",

language = "English",

volume = "9",

pages = "1727--1734",

journal = "Materials Horizons",

issn = "2051-6347",

publisher = "Royal Society of Chemistry",

number = "6",

}

Hybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery. / Gurke, Johannes (Co-first Author); Naegele, Tobias E. (Co-first Author); Hilton, Sam et al.
In: Materials Horizons, Vol. 9, No. 6, 01.06.2022, p. 1727-1734.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Hybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery

AU - Gurke, Johannes

AU - Naegele, Tobias E.

AU - Hilton, Sam

AU - Pezone, Roberto

AU - Curto, Vincenzo F.

AU - Barone, Damiano G.

AU - List-Kratochvil, Emil J. W.

AU - Carnicer-Lombarte, Alejandro

AU - Malliaras, George G.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - New fabrication approaches for mechanically flexible implants hold the key to advancing the applications of neuroengineering in fundamental neuroscience and clinic. By combining the high precision of thin film microfabrication with the versatility of additive manufacturing, we demonstrate a straight-forward approach for the prototyping of intracranial implants with electrode arrays and microfluidic channels. We show that the implant can modulate neuronal activity in the hippocampus through localized drug delivery, while simultaneously recording brain activity by its electrodes. Moreover, good implant stability and minimal tissue response are seen one-week post-implantation. Our work shows the potential of hybrid fabrication combining different manufacturing techniques in neurotechnology and paves the way for a new approach to the development of multimodal implants. © 2022 The Royal Society of Chemistry.

AB - New fabrication approaches for mechanically flexible implants hold the key to advancing the applications of neuroengineering in fundamental neuroscience and clinic. By combining the high precision of thin film microfabrication with the versatility of additive manufacturing, we demonstrate a straight-forward approach for the prototyping of intracranial implants with electrode arrays and microfluidic channels. We show that the implant can modulate neuronal activity in the hippocampus through localized drug delivery, while simultaneously recording brain activity by its electrodes. Moreover, good implant stability and minimal tissue response are seen one-week post-implantation. Our work shows the potential of hybrid fabrication combining different manufacturing techniques in neurotechnology and paves the way for a new approach to the development of multimodal implants. © 2022 The Royal Society of Chemistry.

UR - https://www.scopus.com/pages/publications/85130024386

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85130024386&origin=recordpage

U2 - 10.1039/d1mh01855h

DO - 10.1039/d1mh01855h

M3 - RGC 21 - Publication in refereed journal

C2 - 35474130

SN - 2051-6347

VL - 9

SP - 1727

EP - 1734

JO - Materials Horizons

JF - Materials Horizons

IS - 6

ER -

Hybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery

Abstract

Funding

Publisher's Copyright Statement

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Cite this