Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Xiaoyan Qiu
  • Xiaohui Zhu
  • Yuntao Mao
  • Jian Zhang
  • Peng Hao
  • Guohui Li
  • Peng Lv
  • Zhixin Li
  • Xin Sun
  • Lemeng Wu
  • Jie Zheng
  • Yuqing Deng
  • Chunmei Hou
  • Peixian Tang
  • Shuren Zhang
  • Youhui Zhang

Detail(s)

Original languageEnglish
Pages (from-to)6488-6495
Journal / PublicationCancer Research
Volume63
Issue number19
Publication statusPublished - 1 Oct 2003
Externally publishedYes

Abstract

Immunoglobulins (Igs) are found thus far only to be produced by differentiated B lymphocytes. By immunohistochemistry analysis, in situ hybridization, and laser capture microdissection-assisted single-cell PCR, we demonstrate that human cancers of epithelial origin, including carcinomas of breast, colon, liver, lung, established epithelial cancer lines, as well as some normal lung tissues, also produce IgG in both cytoplasmic and secreted forms. Furthermore, blockade of tumor-derived IgG by either antisense DNA or antihuman IgG antibody increased programmed cell death and inhibited growth of cancer cells in vitro. More importantly, administration of antihuman IgG antibody also suppressed the growth of an IgG-secreting carcinoma line in immunodeficient nude mice. Our results support a role of tumor-derived IgG as growth factor for epithelial cancers. Prevalent expression of IgG in human carcinomas and its growth-promoting functions may have important implications in growth regulation and targeted therapy of human cancers.

Citation Format(s)

Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells. / Qiu, Xiaoyan; Zhu, Xiaohui; Zhang, Liang; Mao, Yuntao; Zhang, Jian; Hao, Peng; Li, Guohui; Lv, Peng; Li, Zhixin; Sun, Xin; Wu, Lemeng; Zheng, Jie; Deng, Yuqing; Hou, Chunmei; Tang, Peixian; Zhang, Shuren; Zhang, Youhui.

In: Cancer Research, Vol. 63, No. 19, 01.10.2003, p. 6488-6495.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review