Hormonal activity of AIMP1/p43 for glucose homeostasis

Sang Gyu Park; Young Sun Kang; Jin Young Kim; Chang Seok Lee; Young Gyu Ko; Woo Je Lee; Ki-Up Lee; Young Il Yeom; Sunghoon Kim

doi:10.1073/pnas.0602045103

Hormonal activity of AIMP1/p43 for glucose homeostasis

Sang Gyu Park, Young Sun Kang, Jin Young Kim, Chang Seok Lee, Young Gyu Ko, Woo Je Lee, Ki-Up Lee, Young Il Yeom, Sunghoon Kim

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

59 Citations (Scopus)

Abstract

AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis. © 2006 by The National Academy of Sciences of the USA.

Original language	English
Pages (from-to)	14913-14918
Journal	PNAS: Proceedings of the National Academy of Sciences of the United States of America
Volume	103
Issue number	40
DOIs	https://doi.org/10.1073/pnas.0602045103
Publication status	Published - 3 Oct 2006
Externally published	Yes

Research Keywords

Aminoacyl-tRNA synthetase
Glucagon
Pancreas

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title = "Hormonal activity of AIMP1/p43 for glucose homeostasis",

abstract = "AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis. {\textcopyright} 2006 by The National Academy of Sciences of the USA.",

keywords = "Aminoacyl-tRNA synthetase, Glucagon, Pancreas",

author = "Park, {Sang Gyu} and Kang, {Young Sun} and Kim, {Jin Young} and Lee, {Chang Seok} and Ko, {Young Gyu} and Lee, {Woo Je} and Ki-Up Lee and Yeom, {Young Il} and Sunghoon Kim",

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TY - JOUR

T1 - Hormonal activity of AIMP1/p43 for glucose homeostasis

AU - Park, Sang Gyu

AU - Kang, Young Sun

AU - Kim, Jin Young

AU - Lee, Chang Seok

AU - Ko, Young Gyu

AU - Lee, Woo Je

AU - Lee, Ki-Up

AU - Yeom, Young Il

AU - Kim, Sunghoon

PY - 2006/10/3

Y1 - 2006/10/3

N2 - AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis. © 2006 by The National Academy of Sciences of the USA.

AB - AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis. © 2006 by The National Academy of Sciences of the USA.

KW - Aminoacyl-tRNA synthetase

KW - Glucagon

KW - Pancreas

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U2 - 10.1073/pnas.0602045103

DO - 10.1073/pnas.0602045103

M3 - RGC 21 - Publication in refereed journal

C2 - 17001013

SN - 0027-8424

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JO - PNAS: Proceedings of the National Academy of Sciences of the United States of America

JF - PNAS: Proceedings of the National Academy of Sciences of the United States of America

IS - 40

ER -

Hormonal activity of AIMP1/p43 for glucose homeostasis

Abstract

Research Keywords

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