Histone H2B Mutations in Cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Article number694
Journal / PublicationBiomedicines
Volume9
Issue number6
Online published19 Jun 2021
Publication statusPublished - Jun 2021

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Abstract

Oncohistones have emerged as a new area in cancer epigenetics research. Recent efforts to catalogue histone mutations in cancer patients have revealed thousands of histone mutations across different types of cancer. In contrast to previously identified oncohistones (H3K27M, H3G34V/R, and H3K36M), where the mutations occur on the tail domain and affect histone post-translational modifications, the majority of the newly identified mutations are located within the histone fold domain and affect gene expression via distinct mechanisms. The recent characterization of the selected H2B has revealed previously unappreciated roles of oncohistones in nucleosome stability, chromatin accessibility, and chromatin remodeling. This review summarizes recent advances in the study of H2B oncohistones and other emerging oncohistones occurring on other types of histones, particularly those occurring on the histone fold domain.

Research Area(s)

  • oncohistone, histone mutation, epigenetics, cancer epigenetics, H2B, H3.3K27M MUTATION, DRIVER MUTATIONS, PEDIATRIC GLIOMA, COMPLEX, H4, METHYLATION, RECOGNITION, REPROGRAMS, REVEAL, DOMAIN

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