Hippocampal interlamellar cell–cell connectome that counts

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Doohyeong Jang
  • Jinho Lee
  • Hongseong Shin
  • Sunggu Yang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Number of pages12
Journal / PublicationJournal of Cellular Physiology
Online published5 Sep 2022
Publication statusOnline published - 5 Sep 2022

Abstract

The hippocampus is regarded as a cognition hub, particularly for learning and memory. Previously, neuronal mechanisms underlying various cognitive functions are delineated with the lamellar hippocampal circuitry, dentate gyrus—CA3 or CA2—CA1, within the transverse plane. More recently, interlamellar (often referred to as longitudinal) projections have received intensive attention to help understand signal convergence and divergence in cognition and behavior. Signal propagation along the longitudinal axis is evidenced by axonal arborization patterns and synaptic responses to electro- and photo-stimulation, further demonstrating that information flow is more enriched in the longitudinal plane than the transverse plane. Here, we review the significance of longitudinal connections for cognition, discuss a putative circuit mechanism of place coding, and suggest the reconceptualization of the hippocampal circuitry.

Research Area(s)

  • feedforward network, longitudinal connection, place coding, spatial memory, synaptic plasticity