HIGH-THROUGHPUT SINGLE CELL PROTEASE ANALYSIS ON HUMAN CIRCULATING TUMOR CELLS

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review

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Author(s)

  • Tengyang Jing
  • Ee Xien Ng
  • Chwee Teck Lim
  • Jongyoon Han

Detail(s)

Original languageEnglish
Title of host publication19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015)
PublisherChemical and Biological Microsystems Society
Pages490-492
Volume1
ISBN (Electronic)9780979806483
ISBN (Print)9781510817876
Publication statusPublished - Oct 2015
Externally publishedYes

Conference

Title19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015)
PlaceKorea, Republic of
CityGyeongju
Period25 - 29 October 2015

Abstract

Detection of circulating tumor cells (CTCs) from cancer patients' blood provides a convenient method for early-stage cancer diagnosis and to monitor disease progression. Many studies have confirmed that tumor consists of a heterogeneous cell composition. Only a small portion of CTCs can persist within the blood circulatory system. Residing CTCs may then extravasate to form a secondary tumor, mediated by the secretion of matrix metalloproteinases (MMP). Here, we present an integrated microfluidic approach for MMP activity measurement on sorted single CTCs. The assay results could contribute to identify CTC subpopulations of different metastatic potential and provide insights into cancer heterogeneity.

Research Area(s)

  • Circulating tumor cell, Matrix metalloproteinases functional assay, Single cell analysis

Citation Format(s)

HIGH-THROUGHPUT SINGLE CELL PROTEASE ANALYSIS ON HUMAN CIRCULATING TUMOR CELLS. / Jing, Tengyang; Ng, Ee Xien; Khoo, Bee Luan et al.

19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Vol. 1 Chemical and Biological Microsystems Society, 2015. p. 490-492.

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review