HIGH-THROUGHPUT SINGLE CELL PROTEASE ANALYSIS ON HUMAN CIRCULATING TUMOR CELLS
Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45) › 32_Refereed conference paper (with ISBN/ISSN) › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Title of host publication | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015) |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 490-492 |
| Volume | 1 |
| ISBN (Electronic) | 9780979806483 |
| ISBN (Print) | 9781510817876 |
| Publication status | Published - Oct 2015 |
| Externally published | Yes |
Conference
| Title | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015) |
|---|---|
| Place | Korea, Republic of |
| City | Gyeongju |
| Period | 25 - 29 October 2015 |
Link(s)
Abstract
Detection of circulating tumor cells (CTCs) from cancer patients' blood provides a convenient method for early-stage cancer diagnosis and to monitor disease progression. Many studies have confirmed that tumor consists of a heterogeneous cell composition. Only a small portion of CTCs can persist within the blood circulatory system. Residing CTCs may then extravasate to form a secondary tumor, mediated by the secretion of matrix metalloproteinases (MMP). Here, we present an integrated microfluidic approach for MMP activity measurement on sorted single CTCs. The assay results could contribute to identify CTC subpopulations of different metastatic potential and provide insights into cancer heterogeneity.
Research Area(s)
- Circulating tumor cell, Matrix metalloproteinases functional assay, Single cell analysis
Citation Format(s)
HIGH-THROUGHPUT SINGLE CELL PROTEASE ANALYSIS ON HUMAN CIRCULATING TUMOR CELLS. / Jing, Tengyang; Ng, Ee Xien; Khoo, Bee Luan et al.
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Vol. 1 Chemical and Biological Microsystems Society, 2015. p. 490-492.Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45) › 32_Refereed conference paper (with ISBN/ISSN) › peer-review
