High-speed photoacoustic microscopy of mouse cortical microhemodynamics

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

24 Scopus Citations
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Author(s)

  • Li Lin
  • Junjie Yao
  • Ruiying Zhang
  • Chun-Cheng Chen
  • Chih-Hsien Huang
  • Yang Li
  • William Chapman
  • Jun Zou
  • Lihong V. Wang

Detail(s)

Original languageEnglish
Pages (from-to)792-798
Journal / PublicationJournal of Biophotonics
Volume10
Issue number6-7
Online published23 Dec 2016
Publication statusPublished - Jun 2017

Abstract

We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.

Citation Format(s)

High-speed photoacoustic microscopy of mouse cortical microhemodynamics. / Lin, Li; Yao, Junjie; Zhang, Ruiying et al.
In: Journal of Biophotonics, Vol. 10, No. 6-7, 06.2017, p. 792-798.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review