High-resolution extracellular stimulation of dispersed hippocampal culture with high-density CMOS multielectrode array based on non-Faradaic electrodes

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

7 Scopus Citations
View graph of relations

Author(s)

  • N. Lei
  • S. Ramakrishnan
  • J. S. Orcutt
  • R. Yuste
  • L. C. Kam
  • K. L. Shepard

Detail(s)

Original languageEnglish
Article number44003
Journal / PublicationJournal of Neural Engineering
Volume8
Issue number4
Publication statusPublished - Aug 2011
Externally publishedYes

Abstract

We introduce a method to electrically stimulate individual neurons at single-cell resolution in arbitrary spatiotemporal patterns with precise control over stimulation thresholds. By exploiting a custom microelectronic chip, up to 65 000 non-Faradaic electrodes can be uniquely addressed with electrode density exceeding 6500 electrodes mm -2. We demonstrate extracellular stimulation of dispersed primary hippocampal neuronal cultures using the chip at single-cell resolution. © 2011 IOP Publishing Ltd.

Citation Format(s)

High-resolution extracellular stimulation of dispersed hippocampal culture with high-density CMOS multielectrode array based on non-Faradaic electrodes. / Lei, N.; Ramakrishnan, S.; Shi, P.; Orcutt, J. S.; Yuste, R.; Kam, L. C.; Shepard, K. L.

In: Journal of Neural Engineering, Vol. 8, No. 4, 44003, 08.2011.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal