Highly Sensitive and Cost-Effective Portable Sensor for Early Gastric Carcinoma Diagnosis

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

3 Scopus Citations
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Detail(s)

Original languageEnglish
Article number2639
Journal / PublicationSensors
Volume21
Issue number8
Online published9 Apr 2021
Publication statusPublished - Apr 2021

Link(s)

Abstract

Facile and efficient early detection of cancer is a major challenge in healthcare. Herein we developed a novel sensor made from a polycarbonate (PC) membrane with nanopores, followed by sequence-specific Oligo RNA modification for early gastric carcinoma diagnosis. In this design, the gastric cancer antigen CA72-4 is specifically conjugated to the Oligo RNA, thereby inhibiting the electrical current through the PC membrane in a concentration-dependent manner. The device can determine the concentration of cancer antigen CA72-4 in the range from 4 to 14 U/mL, possessing a sensitivity of 7.029 µAU−1mLcm−2 with a linear regression (R2) of 0.965 and a lower detection limit of 4 U/mL. This device has integrated advantages including high specificity and sensitivity and being simple, portable, and cost effective, which collectively enables a giant leap for cancer screening technologies towards clinical use. This is the first report to use RNA aptamers to detect CA72-4 for gastric carcinoma diagnosis.

Research Area(s)

  • polycarbonate membrane, cancer antigen, Oligo RNA, cancer early detection, electrical current sensor

Citation Format(s)

Highly Sensitive and Cost-Effective Portable Sensor for Early Gastric Carcinoma Diagnosis. / Oo, Saw Lin; Venkatesh, Shishir; Karthikeyan, Vaithinathan; Arava, Clement Manohar; Pathikonda, Spoorthy; Yu, Peter K. N.; Lau, Terrence C. K.; Chen, Xianfeng; Roy, Vellaisamy A. L.

In: Sensors, Vol. 21, No. 8, 2639, 04.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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