Highly selective mitochondria-targeting amphiphilic silicon(IV) phthalocyanines with axially ligated rhodamine B for photodynamic therapy

Zhixin Zhao; Pui-Shan Chan; Hongguang Li; Ka-Leung Wong; Ricky Ngok Shun Wong; Nai-Ki Mak; Jie Zhang; Hoi-Lam Tam; Wai-Yeung Wong; Daniel W. J. Kwong; Wai-Kwok Wong

doi:10.1021/ic201178e

Highly selective mitochondria-targeting amphiphilic silicon(IV) phthalocyanines with axially ligated rhodamine B for photodynamic therapy

Zhixin Zhao
, Pui-Shan Chan
, Hongguang Li
, Ka-Leung Wong
, Ricky Ngok Shun Wong
, Nai-Ki Mak
, Jie Zhang
, Hoi-Lam Tam
, Wai-Yeung Wong
, Daniel W. J. Kwong
, Wai-Kwok Wong

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

71 Citations (Scopus)

Abstract

Two axially ligated rhodamine-Si(IV)-phthalocyanine (Rh-SiPc) conjugates, bearing one and two rhodamine B, were synthesized and their linear and two-photon photophysical, subcellular localization and photocytotoxic properties were studied. These Rh-SiPc conjugates exhibited an almost exclusive mitochondrial localizing property in human nasopharyngeal carcinoma (HK-1) cells and human cervical carcinoma (HeLa) cells. Strong photocytotoxic but low dark cytotoxic properties were also observed for the two Rh-SiPc conjugates toward the HK-1 cells. Using nuclei staining method and flow cytometric DNA content analysis, apoptotic cell death was induced by these conjugates upon photoactivation. This observation is consistent with their mitochondrial localization property. The observed properties of these conjugates qualify them as promising PDT agents. © 2011 American Chemical Society.

Original language	English
Pages (from-to)	812-821
Journal	Inorganic Chemistry
Volume	51
Issue number	2
DOIs	https://doi.org/10.1021/ic201178e
Publication status	Published - 16 Jan 2012
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

The work described in this paper was partially supported by a grant from the Research Grants Council of the Hong Kong SAR, P.R. China (HKBU 202509 and HKBU 202210) and a grant from the Hong Kong Baptist University (FRG2/09-10/58). W.-Y. Wong and W.-K. Wong also thanks a grant from Areas of Excellence Scheme, University Grants Committee of HKSAR, China (Project No. [AoE/P-03/08]).

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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RGC-funded

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title = "Highly selective mitochondria-targeting amphiphilic silicon(IV) phthalocyanines with axially ligated rhodamine B for photodynamic therapy",

abstract = "Two axially ligated rhodamine-Si(IV)-phthalocyanine (Rh-SiPc) conjugates, bearing one and two rhodamine B, were synthesized and their linear and two-photon photophysical, subcellular localization and photocytotoxic properties were studied. These Rh-SiPc conjugates exhibited an almost exclusive mitochondrial localizing property in human nasopharyngeal carcinoma (HK-1) cells and human cervical carcinoma (HeLa) cells. Strong photocytotoxic but low dark cytotoxic properties were also observed for the two Rh-SiPc conjugates toward the HK-1 cells. Using nuclei staining method and flow cytometric DNA content analysis, apoptotic cell death was induced by these conjugates upon photoactivation. This observation is consistent with their mitochondrial localization property. The observed properties of these conjugates qualify them as promising PDT agents. {\textcopyright} 2011 American Chemical Society.",

author = "Zhixin Zhao and Pui-Shan Chan and Hongguang Li and Ka-Leung Wong and Wong, \{Ricky Ngok Shun\} and Nai-Ki Mak and Jie Zhang and Hoi-Lam Tam and Wai-Yeung Wong and Kwong, \{Daniel W. J.\} and Wai-Kwok Wong",

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AU - Zhao, Zhixin

AU - Chan, Pui-Shan

AU - Li, Hongguang

AU - Wong, Ka-Leung

AU - Wong, Ricky Ngok Shun

AU - Mak, Nai-Ki

AU - Zhang, Jie

AU - Tam, Hoi-Lam

AU - Wong, Wai-Yeung

AU - Kwong, Daniel W. J.

AU - Wong, Wai-Kwok

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PY - 2012/1/16

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N2 - Two axially ligated rhodamine-Si(IV)-phthalocyanine (Rh-SiPc) conjugates, bearing one and two rhodamine B, were synthesized and their linear and two-photon photophysical, subcellular localization and photocytotoxic properties were studied. These Rh-SiPc conjugates exhibited an almost exclusive mitochondrial localizing property in human nasopharyngeal carcinoma (HK-1) cells and human cervical carcinoma (HeLa) cells. Strong photocytotoxic but low dark cytotoxic properties were also observed for the two Rh-SiPc conjugates toward the HK-1 cells. Using nuclei staining method and flow cytometric DNA content analysis, apoptotic cell death was induced by these conjugates upon photoactivation. This observation is consistent with their mitochondrial localization property. The observed properties of these conjugates qualify them as promising PDT agents. © 2011 American Chemical Society.

AB - Two axially ligated rhodamine-Si(IV)-phthalocyanine (Rh-SiPc) conjugates, bearing one and two rhodamine B, were synthesized and their linear and two-photon photophysical, subcellular localization and photocytotoxic properties were studied. These Rh-SiPc conjugates exhibited an almost exclusive mitochondrial localizing property in human nasopharyngeal carcinoma (HK-1) cells and human cervical carcinoma (HeLa) cells. Strong photocytotoxic but low dark cytotoxic properties were also observed for the two Rh-SiPc conjugates toward the HK-1 cells. Using nuclei staining method and flow cytometric DNA content analysis, apoptotic cell death was induced by these conjugates upon photoactivation. This observation is consistent with their mitochondrial localization property. The observed properties of these conjugates qualify them as promising PDT agents. © 2011 American Chemical Society.

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M3 - RGC 21 - Publication in refereed journal

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SN - 0020-1669

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JO - Inorganic Chemistry

JF - Inorganic Chemistry

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ER -

Highly selective mitochondria-targeting amphiphilic silicon(IV) phthalocyanines with axially ligated rhodamine B for photodynamic therapy

Abstract

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